Tanaka Y, Shiozawa S, Morimoto I, Fujita T
Department of Medicine, Kobe University School of Medicine, Japan.
Scand J Immunol. 1990 May;31(5):547-52. doi: 10.1111/j.1365-3083.1990.tb02805.x.
In a serum-free culture containing no zinc, zinc enhanced the proliferation of T cells in response to interleukin 2 (IL-2), and also the in vitro production of IL-2 by T cells. Although the lymphocyte proliferation was partially inhibited by anti-IL-2 antibodies, it was completely inhibited by anti-IL-2 receptor (CD25) antibodies. A Scatchard plot analysis showed that zinc induced the expression of high-affinity receptors for IL-2 on lymphocytes. The results indicated that zinc may be essentially required for IL-2-mediated T-cell activation.
在不含锌的无血清培养体系中，锌可增强T细胞对白介素2（IL-2）的增殖反应，以及T细胞在体外产生IL-2的能力。虽然抗IL-2抗体可部分抑制淋巴细胞增殖，但抗IL-2受体（CD25）抗体可完全抑制该增殖。Scatchard作图分析表明，锌可诱导淋巴细胞上高亲和力IL-2受体的表达。结果表明，锌可能是IL-2介导的T细胞活化所必需的。
