State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing, China.
Prostate Cancer Prostatic Dis. 2013 Jun;16(2):139-44, S1. doi: 10.1038/pcan.2013.6. Epub 2013 Mar 5.
Prostate cancer (PCa) gene expression marker 1 (PCGEM1), a long noncoding RNA, has drawn increasing attention for its important role in PCa. However, the association between genetic variations in the PCGEM1 gene and risk of PCa has not been investigated yet.
We investigated the effect of two tagging single-nucleotide polymorphism (tSNPs; rs6434568 and rs16834898) in PCGEM1 gene on PCa risk in the Chinese men. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association.
We found a significantly decreased risk of PCa for rs6434568 AC and AC/AA genotype (adjusted OR=0.76, 95% CI=0.60-0.97 for AC; adjusted OR=0.76, 95% CI=0.61-0.96 for AC/AA), as well as rs16834898 AC and AC/CC genotype (adjusted OR=0.76, 95% CI=0.59-0.97 for AC; adjusted OR=0.79, 95% CI=0.62-0.99 for AC/CC), compared with the CC and AA genotypes, respectively. When we evaluated these two tSNPs together based on the risk alleles (that is, rs6434568 C and rs16834898 A), we found that the combined genotypes with four risk alleles were associated with an increased risk of PCa compared with those carrying 0-3 risk alleles (1.53, 1.19-1.97), and this increased risk was more pronounced among subjects of≤70 years (1.80, 1.24-2.62), Gleason score≥7 (1.68, 1.28-2.22) and PSA level≥20 (1.64, 1.24-2.18).
Our results indicated that PCGEM1 polymorphisms may contribute to PCa risk in Chinese men. Additional functional analyses are required to detect the detailed mechanism underlying the observed association.
前列腺癌（PCa）基因表达标记 1（PCGEM1）是一种长链非编码 RNA，因其在 PCa 中的重要作用而受到越来越多的关注。然而，PCGEM1 基因的遗传变异与 PCa 的风险之间的关联尚未得到研究。
我们研究了 PCGEM1 基因中的两个标记单核苷酸多态性（tSNPs；rs6434568 和 rs16834898）对中国男性 PCa 风险的影响。使用比值比（OR）和 95%置信区间（CI）来评估关联。
我们发现 rs6434568 AC 和 AC/AA 基因型（调整后的 OR=0.76，95%CI=0.60-0.97 对于 AC；调整后的 OR=0.76，95%CI=0.61-0.96 对于 AC/AA）以及 rs16834898 AC 和 AC/CC 基因型（调整后的 OR=0.76，95%CI=0.59-0.97 对于 AC；调整后的 OR=0.79，95%CI=0.62-0.99 对于 AC/CC）与 CC 和 AA 基因型相比，患 PCa 的风险显著降低。当我们根据风险等位基因（即 rs6434568 C 和 rs16834898 A）一起评估这两个 tSNPs 时，我们发现与携带 0-3 个风险等位基因相比，携带四个风险等位基因的组合基因型与 PCa 风险增加相关（1.53，1.19-1.97），这种风险增加在年龄≤70 岁的患者中更为明显（1.80，1.24-2.62），Gleason 评分≥7（1.68，1.28-2.22）和 PSA 水平≥20（1.64，1.24-2.18）。
我们的结果表明，PCGEM1 多态性可能导致中国男性 PCa 风险增加。需要进行额外的功能分析来检测观察到的关联背后的详细机制。
