Su Yuanshuai, Gu Xinyu, Zheng Qiuxian, Zhu Lingxiao, Lu Juan, Li Lanjuan
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Front Oncol. 2022 Feb 21;12:847745. doi: 10.3389/fonc.2022.847745. eCollection 2022.
As novel members of the noncoding RNA family, long noncoding RNAs (lncRNAs) have been widely reported to function as powerful regulators in gene expression processes, including chromosome remodeling, transcription interference and posttranscriptional modification. With the rapid development of metagenomic sequencing, numerous studies have indicated that the dysregulation of lncRNAs is closely associated with diverse human diseases, especially cancers. Prostate Gene Expression Marker 1 (PCGEM1), a recently identified lncRNA, has been reported to play a crucial role in the initiation and progression of multiple tumors by interacting with pivotal regulators of tumor-related signaling pathways. In this review, we will retrospectively review the recent studies of the expression of lncRNA PCGEM1 in human cancers and comprehensively describe the underlying regulatory mechanism by which PCGEM1 functions in tumors. More importantly, based on the relationship between PCGEM1 and cancers, the potential application of PCGEM1 in clinical diagnosis, prognosis and therapeutic treatment will also be highlighted.
作为非编码RNA家族的新成员，长链非编码RNA（lncRNAs）已被广泛报道在基因表达过程中作为强大的调节因子发挥作用，包括染色体重塑、转录干扰和转录后修饰。随着宏基因组测序的迅速发展，大量研究表明lncRNAs的失调与多种人类疾病密切相关，尤其是癌症。前列腺基因表达标志物1（PCGEM1）是最近发现的一种lncRNA，据报道它通过与肿瘤相关信号通路的关键调节因子相互作用，在多种肿瘤的发生和发展中起关键作用。在这篇综述中，我们将回顾lncRNA PCGEM1在人类癌症中表达的最新研究，并全面描述PCGEM1在肿瘤中发挥作用的潜在调控机制。更重要的是，基于PCGEM1与癌症之间的关系，还将强调PCGEM1在临床诊断、预后和治疗中的潜在应用。
