通过胍基路易斯碱催化的烯丙酸盐的[2+2]环加成反应合成高取代的环氧乙烷。
Synthesis of highly substituted oxetanes via [2+2] cycloaddition reactions of allenoates catalyzed by a guanidine Lewis base.
机构信息
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany.
出版信息
Chem Commun (Camb). 2013 Apr 11;49(28):2930-2. doi: 10.1039/c3cc40855h.
PMID:23459717
Abstract
The first synthesis of highly substituted 3-alkyl-oxetan-2-ylidenes from allenoates was developed by using the bicyclic guanidine 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) as an exceptionally active nitrogen Lewis base catalyst.
摘要
首次通过使用双环胍 1,5,7-三氮杂二环[4.4.0]癸-5-烯（TBD）作为一种极其活泼的氮路易斯碱催化剂，从丙二烯酸酯合成了高度取代的 3-烷基-氧杂环丁-2-亚基。
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