Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, PR China.
J Nutr Health Aging. 2013 Mar;17(3):223-9. doi: 10.1007/s12603-012-0399-z.
To observe the effect of prolonged feeding of dietary nucleotides (NTs), and to clarify the effect of NTs on life extension of Sprague-Dawley rats.
There were 50 Sprague-Dawley rats in each group (male:female ratio=1:1), which were fed diets supplemented with NTs at concentrations of 0%, 0.01%, 0.04%, 0.16% and 0.64% (wt/wt) from the age of 4 weeks until natural death. We investigated the moribundity and mortality, survival time, spontaneous tumor incidence, and serum oxidative status.
NTs have significantly influence body weight of first 3 month old and food consumption of male rats throughout the life span; it did dose-dependently inhibit the age-related decrease in the activities of antioxidant enzymes and the age-related increase in the levels of lipid peroxidation product in both sexes. NTs notably increased the mean life span, and the maximal life span. Compared to the control group, the incidence of death from tumors was decreased in NTs groups of both sexes.
Long-term feeding of NTs could dose-dependently increase life span in Sprague-Dawley rats, especially, the tumor-bearing ones. Moreover, the antioxidative property of NTs may be responsible for the increased life span.
观察长期喂养膳食核苷酸（NTs）的效果，阐明 NTs 对延长 Sprague-Dawley 大鼠寿命的影响。
每组各有 50 只 Sprague-Dawley 大鼠（雌雄比例 1:1），从 4 周龄开始用 NTs 浓度为 0%、0.01%、0.04%、0.16%和 0.64%（wt/wt）的饲料喂养至自然死亡。我们研究了濒死率和死亡率、生存时间、自发性肿瘤发生率和血清氧化状态。
NT 显著影响 3 月龄以下大鼠的体重和雄性大鼠整个寿命期间的食物消耗；它呈剂量依赖性抑制了抗氧化酶活性随年龄的下降和两性脂质过氧化产物水平随年龄的升高。NT 明显增加了平均寿命和最大寿命。与对照组相比，两性 NT 组的肿瘤致死率降低。
长期喂养 NTs 可剂量依赖性地延长 Sprague-Dawley 大鼠的寿命，特别是肿瘤负荷大鼠的寿命。此外，NTs 的抗氧化特性可能是其延长寿命的原因。
