Volkova N A, Karpliuk I A
Vopr Pitan. 1990 Jan-Feb(1):74-6.
The micronuclear test was used to study cadmium chloride mutagenic activity. The investigation was conducted in an acute experiment on noninbred white mice. Cadmium chloride was administered to four groups of mice (6 mice in each group) intragastrically in doses of 100, 10.2 and 1 microgram/kg (recalculated for cadmium). Control mice received water by the same route. After two administrations of cadmium with a 24-hour interval the animals were sacrificed. The bone marrow preparations were made to analyze the number of polychromophilic red blood cells with micronuclei on 1000 polychromophilic red blood cells detected in the preparation. The results of the analysis were treated according to the Fisher's criterion. The data obtained, compared with literature information, have permitted a suggestion that cadmium administered intragastrically, both in low and high doses, possesses no mutagenic activity with respect to somatic cells.
微核试验用于研究氯化镉的诱变活性。该研究在非近交系白色小鼠的急性实验中进行。将氯化镉以100、10.2和1微克/千克（按镉重新计算）的剂量经胃内给予四组小鼠（每组6只小鼠）。对照小鼠经相同途径给予水。在间隔24小时进行两次镉给药后，处死动物。制备骨髓涂片，以分析在涂片检测到的1000个嗜多染红细胞中含微核的嗜多染红细胞数量。根据费舍尔准则处理分析结果。将获得的数据与文献信息进行比较，结果表明，经胃内给予的低剂量和高剂量镉对体细胞均无诱变活性。
