[氯化镉在哺乳动物中的诱变作用]

[Mutagenic action of cadmium chloride in mammals].

作者信息

Kozachenko V I, Pashin Iu V, Soboleva L S, Sal'nikova L E

出版信息

Nauchnye Doki Vyss Shkoly Biol Nauki. 1987(11):102-5.

Abstract

The mutagenic effect of cadmium chloride on somatic cells of F1 hybrid mice CBA X C57B1/6J in vivo and on an established line of CHO-ATZ-2 Chinese hamster cells in vitro has been studied. The induction of micronuclei has been demonstrated in mouse marrow cells as well as induction of point mutations at loci controlling the synthesis of hypoxanthine-phosphoribosyltransferase, thymidine kinase, adenine phosphoribosyltransferase and the resistance of Na+/K+ ATPase to ouabain in the cell line CHO-AT-2. A peak of mutagenic activity under the action of subtoxic doses of cadmium chloride has been revealed.

摘要

研究了氯化镉对F1代杂种小鼠CBA×C57B1/6J体细胞的体内诱变作用以及对已建立的中国仓鼠CHO-ATZ-2细胞系的体外诱变作用。在小鼠骨髓细胞中已证实有微核诱导现象，并且在CHO-AT-2细胞系中，在控制次黄嘌呤-磷酸核糖转移酶、胸苷激酶、腺嘌呤磷酸核糖转移酶合成的基因座上有基因突变诱导现象，以及Na+/K+ATP酶对哇巴因的抗性也有改变。已揭示出在亚毒性剂量氯化镉作用下诱变活性的峰值。