Department of Preventive Medicine, School of Public Health, Soochow University, Suzhou, China.
Geriatr Gerontol Int. 2013 Oct;13(4):817-24. doi: 10.1111/ggi.12044. Epub 2013 Mar 6.
Statins are a class of medications that reduce cholesterol by inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A reductase, which were thought to have a positive impact on dementia. We carried out the present meta-analysis to investigate whether statins might be associated with a reduction on risk of dementia. We carried out a meta-analysis of prospective cohort studies to examine the risk of dementia associated with statins. Ovid-Medline database, PubMed database, Springer Link database and Google Scholar in English search were carried out for relevant studies. Selected studies had to describe an original study defined by strict screening and diagnostic criteria. We included eight prospective cohort studies that reported relative risks with 95% confidence intervals for the association of statins and dementia risk. A random effects model was used to calculate the summary risk estimates. The studies eligible for analysis involved 2851 cases and 57020 participants. The summary relative risk of dementia for the use of statins was 0.62 (95% confidence interval 0.43-0.81), with evidence of heterogeneity (P = 0.001, I(2) = 70.8%). Findings of the present meta-analysis show that statin use was associated with a reduced risk of dementia.
他汀类药物是一类通过抑制 3-羟基-3-甲基戊二酰辅酶 A 还原酶降低胆固醇的药物，人们认为它们对痴呆症有积极影响。我们进行了本次荟萃分析，以调查他汀类药物是否与降低痴呆风险有关。我们对前瞻性队列研究进行了荟萃分析，以研究他汀类药物与痴呆风险的关联。我们用英文在 Ovid-Medline 数据库、PubMed 数据库、施普林格链接数据库和谷歌学术上进行了相关研究的检索。选择的研究必须描述符合严格筛选和诊断标准的原始研究。我们纳入了 8 项前瞻性队列研究，这些研究报告了他汀类药物与痴呆风险关联的相对风险及其 95%置信区间。使用随机效应模型计算汇总风险估计值。有分析资格的研究涉及 2851 例病例和 57020 名参与者。使用他汀类药物的痴呆症综合相对风险为 0.62（95%置信区间 0.43-0.81），存在异质性证据（P = 0.001，I² = 70.8%）。本次荟萃分析的结果表明，使用他汀类药物与痴呆风险降低有关。
