Mulchandani Rubina, Kakkar Ashish Kumar, Gandotra Sheetal, Isser H S, Dhamija Rajinder K, Lyngdoh Tanica
Indian Institute of Public Health-Delhi, Public Health Foundation of India, Gurgaon, India.
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
JRSM Cardiovasc Dis. 2025 Sep 3;14:20480040251371770. doi: 10.1177/20480040251371770. eCollection 2025 Jan-Dec.
Statins are the most widely prescribed drugs for dyslipidemia and CAD. But evidence on their cognitive effects is conflicting. A unique genetic makeup and variable lipid patterns make South Asians more susceptible to statin adverse effects. But literature on statin safety in this group is scarce. We aimed to assess the cognitive status of adult Indian statin users over two years and explore factors associated with it.
A prospective cohort was established for cognitive profiling of adult statin users, visiting the out-patient cardiology department of a tertiary care center in North India. The Montreal Cognitive Assessment Scale measured cognitive function. Analysis was conducted using mixed-effects linear regression modelling to account for repeated measurements.
273 participants were enrolled. The mean cognitive score was 15. Age and education were significant predictors of cognition (-value .005 and <.001 respectively). Participants over 60 scored had significantly lower scores and those who had completed secondary school and above scored significantly higher scores. No significant associations were observed between cognitive score and other covariates- sex, follow-up period, statin type and duration of use.
The statins-cognition relationship is controversial. This study demonstrated statistically significant relationships of cognition with age and education and showed no change in cognition over 2 years. The findings provide hypotheses for more in-depth assessments. Statins remain the most effective lipid-lowering treatment. However, further research is warranted for a more holistic understanding of the issue & optimizing their risk-benefit ratio.
他汀类药物是治疗血脂异常和冠心病最常用的药物。但其对认知的影响证据存在矛盾。独特的基因构成和不同的血脂模式使南亚人更容易受到他汀类药物不良反应的影响。但关于该群体中他汀类药物安全性的文献较少。我们旨在评估成年印度他汀类药物使用者两年内的认知状态，并探索与之相关的因素。
建立一个前瞻性队列，对成年他汀类药物使用者进行认知分析，这些使用者前往印度北部一家三级护理中心的门诊心脏病科就诊。使用蒙特利尔认知评估量表测量认知功能。采用混合效应线性回归模型进行分析，以考虑重复测量。
共纳入273名参与者。平均认知得分为15分。年龄和教育程度是认知的显著预测因素（分别为P值0.005和<0.001）。60岁以上的参与者得分显著较低，而完成中学及以上教育的参与者得分显著较高。在认知得分与其他协变量（性别、随访期、他汀类药物类型和使用时长）之间未观察到显著关联。
他汀类药物与认知的关系存在争议。本研究证明了认知与年龄和教育程度之间具有统计学意义的关系，并显示两年内认知无变化。这些发现为更深入的评估提供了假设。他汀类药物仍然是最有效的降脂治疗药物。然而，有必要进行进一步研究，以更全面地理解该问题并优化其风险效益比。
