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碳酸酐酶抑制剂:社论。

Carbonic anhydrase inhibitors: an editorial.

出版信息

Expert Opin Ther Pat. 2013;23(6):677-9. doi: 10.1517/13543776.2013.778246. Epub 2013 Mar 6.

Abstract

This issue of Expert Opinion on Therapeutic Patents is dedicated to carbonic anhydrase (CA, EC 4.2.1.1) inhibitors (CAIs), a highly dynamic research topic in the last years. Several review articles and patent analyses on diuretics and antiglaucoma, antiepileptic, anti-obesity and anticancer agents belonging to the pharmacological class of the CAIs are presented, together with a review on bacterial, fungal and protozoan CAs and their inhibition as a novel means of designing anti-infectives.

摘要

本期《治疗专利专家意见》专刊聚焦于碳酸酐酶(CA,EC 4.2.1.1)抑制剂(CAI),这是近年来极具活力的研究课题。本文呈现了几篇关于 CAI 类药理学利尿剂和抗青光眼、抗癫痫、抗肥胖和抗癌药物的综述文章和专利分析,并对细菌、真菌和原生动物 CA 及其抑制作用进行了综述,这为设计抗感染药物提供了新的手段。

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