环状 RNA：剪接的谜之变奏。
Circular RNAs: splicing's enigma variations.
机构信息
Directors' Research, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
出版信息
EMBO J. 2013 Apr 3;32(7):923-5. doi: 10.1038/emboj.2013.53. Epub 2013 Mar 5.
Abstract
Nature advance online publication February 27 2013; doi:; DOI: 10.1038/nature11993 Nature advance online publication February 27 2013; doi:; DOI: 10.1038/nature11928 Circular (circ)RNAs are to transcriptomics what the famous hidden musical theme is to Elgar’s : woven into the entire composition but not unambiguously identified or understood by scholars to this day. Now, two studies (Hansen et al, 2013; Memczak et al, 2013) have made substantial progress in both, identifying thousands of circRNAs and beginning to crack the enigma of their cellular function, by demonstrating that the circRNAs CiRS-7/CDR1as and SRY function as natural and highly stable sponges for specific microRNAs.
摘要
自然通讯在线发表 2013 年 2 月 27 日；doi:;DOI: 10.1038/nature11993 自然通讯在线发表 2013 年 2 月 27 日；doi:;DOI: 10.1038/nature11928 环状 RNA（circRNA）之于转录组学，正如著名的隐藏音乐主题之于艾尔加（Elgar）：它编织在整个作品中，但至今仍未被学者们明确识别或理解。现在，两项研究（Hansen 等人，2013 年；Memczak 等人，2013 年）在这两个方面都取得了重大进展，通过证明 circRNA CiRS-7/CDR1as 和 SRY 作为特定 microRNA 的天然且高度稳定的海绵，鉴定了数千个 circRNA，并开始破解其细胞功能的奥秘。
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