Gallagher R P, McLean D I, Yang C P, Coldman A J, Silver H K, Spinelli J J, Beagrie M
Division of Epidemiology, Cancer Control Agency of British Columbia, Vancouver, Canada.
Arch Dermatol. 1990 Jun;126(6):770-6.
The association between prevalence of benign melanocytic nevi and a number of skin cancer risk factors was examined among 913 white Vancouver (Canada) school children aged 6 to 18 years. Subjects with light skin, with a propensity to burn rather than tan in the sun, and with numerous or severe sunburns in the previous 5 years had significantly higher nevus counts than individuals without these characteristics. Subjects who acquired deeper tans tended to have fewer nevi than those who did not tan. Finally, children who freckled had higher nevus counts than those who did not freckle. These findings in children are similar to those seen in studies of malignant melanoma among adults and suggest that strategies to reduce melanoma incidence should begin with young children.
在加拿大温哥华913名6至18岁的白人学童中,研究了良性黑素细胞痣的患病率与多种皮肤癌风险因素之间的关联。皮肤白皙、在阳光下倾向于晒伤而非晒黑、以及在过去5年中有多次或严重晒伤的受试者,其痣的数量明显高于没有这些特征的个体。晒出较深肤色的受试者往往比不晒黑的受试者痣更少。最后,有雀斑的儿童比没有雀斑的儿童痣的数量更多。儿童中的这些发现与成人恶性黑色素瘤研究中的发现相似,这表明降低黑色素瘤发病率的策略应从幼儿开始。