Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Ludwig-Maximilians-University, Munich, Germany.
Int J Geriatr Psychiatry. 2013 Nov;28(11):1197-204. doi: 10.1002/gps.3944. Epub 2013 Mar 6.
The aim of the study was to compare criterion validities of the WHO-Five Well-being Index (WHO-5) and the Geriatric Depression Scale 15-item version (GDS-15) and 4-item version (GDS-4) as screening instruments for depression in nursing home residents.
Data from 92 residents aged 65-97 years without severe cognitive impairment (Mini Mental State Examination ≥15) were analysed. Criterion validities of the WHO-5, the GDS-15 and the GDS-4 were assessed against diagnoses of major and minor depression provided by the Structured Clinical Interview for DSM-IV. Subanalyses were performed for major and minor depression. Areas under the receiver operating curve (AUCs) as well as sensitivities and specificities at optimal cut-off points were computed.
Prevalence of depressive disorder was 28.3%. The AUC value of the WHO-5 (0.90) was similar to that of the GDS-15 (0.82). Sensitivity of the WHO-5 (0.92) at its optimal cut-off of ≤12 was significantly higher than that of the GDS-15 (0.69) at its optimal cut-off of ≥7. The WHO-5 was equally sensitive for the subgroups of major and minor depression (0.92), whereas the GDS-15 was sensitive only for major depression (0.85), but not for minor depression (0.54). For specificity, there was no significant difference between WHO-5 (0.79) and GDS-15 (0.88), but both instruments outperformed the GDS-4 (0.53).
The WHO-5 demonstrated high sensitivity for major and minor depression. Being shorter than the GDS-15 and superior to the GDS-4, the WHO-5 is a promising screening tool that could help physicians improve low recognition rates of depression in nursing home residents.
本研究旨在比较世界卫生组织五维度健康指数(WHO-5)和老年抑郁量表 15 项版本(GDS-15)及 4 项版本(GDS-4)作为养老院居民抑郁筛查工具的效标效度。
分析了 92 名年龄在 65-97 岁之间且无严重认知障碍(简易精神状态检查≥15)的居民的数据。采用 DSM-IV 结构化临床访谈对 WHO-5、GDS-15 和 GDS-4 的评分与重度和轻度抑郁症的诊断结果进行了比较。对重度和轻度抑郁症进行了亚分析。计算了受试者工作特征曲线下面积(AUC)以及最佳截断点的敏感度和特异度。
抑郁障碍的患病率为 28.3%。WHO-5 的 AUC 值(0.90)与 GDS-15(0.82)相似。WHO-5 的最佳截断值≤12 时的敏感度(0.92)显著高于 GDS-15 的最佳截断值≥7 时的敏感度(0.69)。WHO-5 对重度和轻度抑郁症亚组均具有相同的敏感度(0.92),而 GDS-15 仅对重度抑郁症敏感(0.85),对轻度抑郁症不敏感(0.54)。在特异性方面,WHO-5(0.79)与 GDS-15(0.88)之间无显著差异,但两者均优于 GDS-4(0.53)。
WHO-5 对重度和轻度抑郁症具有较高的敏感度。与 GDS-15 相比,WHO-5 更短,且优于 GDS-4,是一种很有前途的筛查工具,可以帮助医生提高养老院居民抑郁识别率。