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老年抑郁量表最初的30项版本及简化版本在养老院患者中的诊断准确性。

Diagnostic accuracy of the original 30-item and shortened versions of the Geriatric Depression Scale in nursing home patients.

作者信息

Jongenelis K, Pot A M, Eisses A M H, Gerritsen D L, Derksen M, Beekman A T F, Kluiter H, Ribbe M W

机构信息

VU Medical Centre/Institute for Research in Extramural Medicine, Department of Nursing Home Medicine, Department of Psychiatry, Amsterdam, The Netherlands.

出版信息

Int J Geriatr Psychiatry. 2005 Nov;20(11):1067-74. doi: 10.1002/gps.1398.

Abstract

OBJECTIVE

To determine the diagnostic accuracy of the 30-item and shortened versions of the Geriatric Depression Scale (GDS) in diagnosing depression in older nursing home patients.

METHOD

Three hundred and thirty-three older nursing home patients participated in a prospective cross-sectional study in the Netherlands. Sensitivity and specificity, positive and negative predictive values, and the area under the receiver operating curve (ROC) were assessed. Cronbach alphas were also calculated. Both major depression (MDD) and minor depression (MinD) according to the DSM-IV criteria, measured with the Schedules of Clinical Assessment in Neuropsychiatry (SCAN), were used as 'gold standard'.

RESULTS

The cut-off point > or = 11 on the GDS-30 gave a sensitivity of 96.3% for MDD and 85.1% for MinD, with a specificity of 69.1%. The sensitivity of most of the shortened versions was sufficient, varying between 88.9% and 100% for MDD, and between 63.8% and 97.9% for MinD. With regard to the shortened versions, best sensitivity (96.3% and 78.7%) and specificity (69.5%) were found for the GDS-10 developed by D'Ath et al. (1994). The specificity rates for most of the shortened versions were found to be less satisfactory, varying between 18.9% and 74.1%. Sufficient internal consistency was found for the GDS-30, the GDS-15, the GDS-12 and the GDS-10, with Cronbach's alphas varying between 0.88 and 0.72.

CONCLUSIONS

The GDS-30 was found to be a valid and reliable case-finding tool for both major and minor depression in nursing home patients with no cognitive impairment and in patients with mild to moderate cognitively impairment (MMSE > or = 15). The GDS-10 (D'Ath et al., 1994) appeared to be the best least time-consuming alternative for the nursing home setting.

摘要

目的

确定老年抑郁量表(GDS)的30项版本及简化版本对老年疗养院患者抑郁症的诊断准确性。

方法

333名老年疗养院患者参与了荷兰的一项前瞻性横断面研究。评估了敏感性和特异性、阳性和阴性预测值以及受试者工作特征曲线(ROC)下的面积。还计算了克朗巴哈系数。根据《神经精神病学临床评估量表》(SCAN)测量的符合DSM-IV标准的重度抑郁症(MDD)和轻度抑郁症(MinD)均用作“金标准”。

结果

GDS-30上的分界点≥11时,对MDD的敏感性为96.3%,对MinD的敏感性为85.1%,特异性为69.1%。大多数简化版本的敏感性足够,MDD的敏感性在88.9%至100%之间,MinD的敏感性在63.8%至97.9%之间。对于简化版本,D'Ath等人(1994年)开发的GDS-10的敏感性最佳(分别为96.3%和78.7%),特异性为69.5%。大多数简化版本的特异性率不太令人满意,在18.9%至74.1%之间。GDS-30、GDS-15、GDS-12和GDS-10具有足够的内部一致性,克朗巴哈系数在0.88至0.72之间。

结论

对于无认知障碍的疗养院患者以及轻度至中度认知障碍(MMSE≥15)的患者,GDS-30被发现是诊断重度和轻度抑郁症的有效且可靠的病例筛查工具。GDS-10(D'Ath等人,1994年)似乎是疗养院环境中最佳且最省时的替代方案。

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