无催化剂、一锅法三组分 α-取代硝基乙酸酯的氨甲基化反应：溶剂甲醇对反应加速效应的理论和实验研究。
A catalyst-free, one-pot three-component aminomethylation of α-substituted nitroacetates: theoretical and experimental studies into the rate-accelerating effects of the solvent methanol.
机构信息
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, Shanghai 200062, China.
出版信息
Chem Asian J. 2013 May;8(5):877-82. doi: 10.1002/asia.201300053. Epub 2013 Mar 5.
PMID:23463603
Abstract
3, 2, 1 go! An unprecedented one-pot, catalyst-free, three-component aminomethylation of α-substituted nitroacetates, formalin, and amines has been reported, thereby enabling the highly efficient synthesis of α,β-diamino acid precursors with great structural diversity.
摘要
3、2、1，开始！本文报道了首例无催化剂、一锅法的α-取代硝基乙酸盐、甲醛和胺的三组分氨甲基化反应，从而能够高效合成具有丰富结构多样性的α,β-二氨基酸前体。
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