Department of Stomatology, Children's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
J Zhejiang Univ Sci B. 2013 Mar;14(3):253-8. doi: 10.1631/jzus.B1200072.
To evaluate the pharmacological effects of traditional Chinese medicine, bear bile capsule and Huangqi granule, on recurrent parotitis in children.
In this prospective, controlled, and randomized study, a total of 151 young children were divided into three groups: Group A included massaging the children's parotid region and melting vitamin C in their mouth daily; Group B included swallowing bear bile capsule and Huangqi granule daily; and Group C included massages and vitamin C as prescribed in Group A, and traditional Chinese medicine as prescribed in Group B. Children were treated individually for one month and then a follow-up study was conducted for 1 to 3.5 years. Analysis of variance (ANOVA) and Ridit analysis were employed for statistical analysis.
The recurrence rate decreased in every group, but was significantly more in Groups B and C when compared to Group A. The recurrences significantly decreased (P<0.01) in Group B and their recovery rate was as high as 63%, significantly better than those of the other groups (P<0.01).
Huangqi and bear bile could be a novel clinical approach for treating recurrent parotitis in children.
评价中药熊胆胶囊和黄芪颗粒对小儿复发性腮腺炎的药理作用。
采用前瞻性、对照、随机分组的方法，将 151 例患儿分为 3 组：A 组为按摩腮腺区、口含维生素 C 每日融化；B 组为口服熊胆胶囊和黄芪颗粒；C 组为 A 组按摩和维生素 C 口服，B 组中药治疗。每个患儿单独治疗 1 个月，然后随访 1 至 3.5 年。采用方差分析和 Ridit 分析进行统计学分析。
各组的复发率均降低，但 B 组和 C 组明显低于 A 组。B 组复发率明显降低（P<0.01），其治愈率高达 63%，明显优于其他组（P<0.01）。
黄芪和熊胆可能是治疗小儿复发性腮腺炎的一种新的临床方法。
