[免疫异常在儿童复发性腮腺炎中的作用]

[Role of immunologic abnormality in recurrent parotitis in children].

作者信息

Yuan Wen-hua, Su Ji-mei, Ye Xiao-wei, Huang Xiao-jia, Wu Zhi-fang

机构信息

Department of Stomatology, The Affiliated Children's Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.

出版信息

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2010 Jul;39(4):419-23. doi: 10.3785/j.issn.1008-9292.2010.04.015.

DOI:10.3785/j.issn.1008-9292.2010.04.015

PMID:20731044

Abstract

OBJECTIVE

To investigate the relationship between immune function and the recurrent parotitis (RP) for children.

METHODS

The children diagnosed as RP were divided into two groups: aged under 6y and over 6y and the immune function were measured and compared with that of normal children.

RESULTS

For RP children the ratio of CD4+ T cell in over 6y group was significantly lower than that in under 6y group (P<0.05), while IgG value in over 6y group was higher than that in under 6y group (P<0.05). Compared with normal children, RP children in under 6y group had higher CD8+ T cell ratio and IgG, IgE, IgA and C3 value (P<0.01) and lower CD4+ T cell ratio (P<0.01), while RP children over 6y group, they had higher CD8+ T cell ratio, IgE value (P<0.01) and C3 (P<0.05), lower CD4<T cell ratio than those in control group (P<0.01). IgE value and CD8+ T cell ratio in under 6y group were higher than those over 6y control group (P<0.01).

CONCLUSION

Impaired immune function may play an important role in the recurrent parotitis in children.

摘要

目的

探讨儿童免疫功能与复发性腮腺炎（RP）之间的关系。

方法

将确诊为RP的儿童分为两组：6岁以下组和6岁以上组，并检测其免疫功能，与正常儿童进行比较。

结果

RP患儿中，6岁以上组CD4+T细胞比例显著低于6岁以下组（P<0.05），而6岁以上组IgG值高于6岁以下组（P<0.05）。与正常儿童相比，6岁以下组RP患儿的CD8+T细胞比例、IgG、IgE、IgA和C3值较高（P<0.01），CD4+T细胞比例较低（P<0.01）；而6岁以上组RP患儿的CD8+T细胞比例、IgE值较高（P<0.01），C3值较高（P<0.05），CD4+T细胞比例低于对照组（P<0.01）。6岁以下组的IgE值和CD8+T细胞比例高于6岁以上组（P<0.01）。