血小板活化因子对分离的豚鼠壁细胞摄取[14C]氨基比林的影响。
The effect of platelet-activating factor on [14C]aminopyrine uptake by isolated guinea pig parietal cells.
作者信息
Nogami M, Suko M, Miyamoto T
机构信息
Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Japan.
出版信息
Biochem Biophys Res Commun. 1990 May 16;168(3):1047-52. doi: 10.1016/0006-291x(90)91135-f.
C16- and C18- platelet-activating factor (PAF) at 10(-6) M enhanced the uptake of [14C]aminopyrine (AP) by isolated guinea pig parietal cells. This increase was inhibited by a PAF antagonist CV-6209. In a medium with a low calcium (Ca2+) concentration (2 uM), this increase was not observed, which indicates that the increase of AP uptake by PAF is dependent on extracellular Ca2+. PAF and lyso-PAF showed no effect on AP uptake in the presence of histamine or carbachol.
10⁻⁶ M的C16 - 和C18 - 血小板活化因子（PAF）增强了分离的豚鼠壁细胞对[¹⁴C]氨基比林（AP）的摄取。PAF拮抗剂CV - 6209可抑制这种增加。在低钙（Ca²⁺）浓度（2 μM）的培养基中，未观察到这种增加，这表明PAF引起的AP摄取增加依赖于细胞外Ca²⁺。在组胺或卡巴胆碱存在的情况下，PAF和溶血PAF对AP摄取没有影响。
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