Babu P P, Vemuri M C
School of Life Sciences, University of Hyderabad, India.
Biochem Int. 1990;20(3):573-7.
Plasma membrane proteins were isolated from control and ethanol-treated rat livers by the use of two-dimensional gel electrophoresis (IEF-SDS-PAGE). Two groups of proteins differing in their response to ethanol were analysed and termed as ethanol-sensitive proteins (ESP) and ethanol insensitive proteins (EISP). This study indicates a loss of many membrane-associated proteins and strongly suggests a role for these proteins in the mechanism of plasma membrane disruption by ethanol.
通过二维凝胶电泳（IEF-SDS-PAGE）从对照和乙醇处理的大鼠肝脏中分离出质膜蛋白。分析了两组对乙醇反应不同的蛋白质，并将其称为乙醇敏感蛋白（ESP）和乙醇不敏感蛋白（EISP）。这项研究表明许多膜相关蛋白的丢失，并强烈暗示这些蛋白在乙醇破坏质膜的机制中发挥作用。
