Rajtar G
Department of Pharmacology, School of Medicine, Lublin.
Acta Physiol Pol. 1988 Jul-Aug;39(4):276-80.
Rats received ethanol as their only drinking fluid for 4 weeks in a concentration ranging from 6-20%. After the ethanol-free intervals of 24, 48, 72, 96, 120 and 144 hours, the livers were isolated and perfused with 100 ml of perfusion fluid with an addition of ethanol (0.2% f.c.) and the elimination of ethanol from the perfusate was studied. The livers of animals chronically exposed to ethanol showed significant diminution of ethanol elimination from perfusate after 72, 96 and 120 hours of withdrawal. After 144 hours the rate of the ethanol elimination returned to the control level.
大鼠连续4周将乙醇作为唯一饮用液体，浓度范围为6%-20%。在经过24、48、72、96、120和144小时无乙醇间隔期后，分离肝脏并用100毫升添加了乙醇（0.2%体积分数）的灌注液进行灌注，研究灌注液中乙醇的清除情况。长期接触乙醇的动物肝脏在戒断72、96和120小时后，灌注液中乙醇的清除显著减少。144小时后，乙醇清除率恢复到对照水平。
