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The hepatitis E virus capsid C-terminal region is essential for the viral life cycle: implication for viral genome encapsidation and particle stabilization.戊型肝炎病毒衣壳 C 端区域是病毒生命周期所必需的：对病毒基因组包装和粒子稳定的影响。
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本文引用的文献

1
Structure of hepatitis E viral particle.戊型肝炎病毒粒子的结构。
Virus Res. 2011 Oct;161(1):59-64. doi: 10.1016/j.virusres.2011.03.015. Epub 2011 Apr 1.
2
Spatial configuration of hepatitis E virus antigenic domain.戊型肝炎病毒抗原结构域的空间构型。
J Virol. 2011 Jan;85(2):1117-24. doi: 10.1128/JVI.00657-10. Epub 2010 Nov 10.
3
Structure of hepatitis E virion-sized particle reveals an RNA-dependent viral assembly pathway.戊型肝炎病毒样颗粒结构揭示了一种依赖 RNA 的病毒组装途径。
J Biol Chem. 2010 Oct 22;285(43):33175-33183. doi: 10.1074/jbc.M110.106336. Epub 2010 Aug 18.
4
Hepatitis E Virus (HEV) strains in serum samples can replicate efficiently in cultured cells despite the coexistence of HEV antibodies: characterization of HEV virions in blood circulation.血清样本中的戊型肝炎病毒 (HEV) 株尽管存在 HEV 抗体仍能在培养细胞中有效复制：血液循环中 HEV 病毒粒子的特征。
J Clin Microbiol. 2010 Apr;48(4):1112-25. doi: 10.1128/JCM.02002-09. Epub 2010 Jan 27.
5
Inhibition of Hepatitis E virus replication using short hairpin RNA (shRNA).利用短发夹 RNA(shRNA)抑制戊型肝炎病毒复制。
Antiviral Res. 2010 Mar;85(3):541-50. doi: 10.1016/j.antiviral.2010.01.005. Epub 2010 Jan 25.
6
Structure of the hepatitis E virus-like particle suggests mechanisms for virus assembly and receptor binding.戊型肝炎病毒样颗粒的结构揭示了病毒组装和受体结合的机制。
Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12992-7. doi: 10.1073/pnas.0904848106. Epub 2009 Jul 21.
7
Biological and immunological characteristics of hepatitis E virus-like particles based on the crystal structure.基于晶体结构的戊型肝炎病毒样颗粒的生物学和免疫学特性
Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12986-91. doi: 10.1073/pnas.0903699106. Epub 2009 Jul 20.
8
Molecular biology and pathogenesis of hepatitis E virus.戊型肝炎病毒的分子生物学与发病机制
J Biosci. 2008 Nov;33(4):451-64. doi: 10.1007/s12038-008-0064-1.
9
Mutations within potential glycosylation sites in the capsid protein of hepatitis E virus prevent the formation of infectious virus particles.戊型肝炎病毒衣壳蛋白潜在糖基化位点内的突变会阻止传染性病毒颗粒的形成。
J Virol. 2008 Feb;82(3):1185-94. doi: 10.1128/JVI.01219-07. Epub 2007 Nov 21.
10
Development and evaluation of an efficient cell-culture system for Hepatitis E virus.戊型肝炎病毒高效细胞培养系统的开发与评估
J Gen Virol. 2007 Mar;88(Pt 3):903-911. doi: 10.1099/vir.0.82535-0.

戊型肝炎病毒衣壳 C 端区域是病毒生命周期所必需的：对病毒基因组包装和粒子稳定的影响。

The hepatitis E virus capsid C-terminal region is essential for the viral life cycle: implication for viral genome encapsidation and particle stabilization.

机构信息

Department of Virology II, National Institute of Infectious Diseases, Gakuen, Musashi-murayama, Tokyo, Japan.

出版信息

J Virol. 2013 May;87(10):6031-6. doi: 10.1128/JVI.00444-13. Epub 2013 Mar 6.

DOI:10.1128/JVI.00444-13
PMID:23468481
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3648136/
Abstract

Although the C-terminal 52 amino acids (C52aa) of hepatitis E virus (HEV) capsid are not essential for morphology, the C52aa-encoding region is required for replication. Transfection of a C52aa knockdown mutant showed transient growth, and the earliest population included a majority of noninfectious (possibly empty) particles and a minority of infectious particles with C-terminal capsid degradation. Finally, the complete revertant was generated reproducibly. C52aa is essential for the viral life cycle, promoting accurate encapsidation and stabilizing encapsidated particles.

摘要

尽管肝炎 E 病毒（HEV）衣壳的 C 末端 52 个氨基酸（C52aa）对形态不是必需的，但 C52aa 编码区是复制所必需的。转染 C52aa 敲低突变体显示出短暂的生长，最早的种群包括大多数无传染性（可能为空）颗粒和少数具有 C 末端衣壳降解的传染性颗粒。最后，可重复性地生成了完全回复突变体。C52aa 对病毒生命周期至关重要，促进了准确的包裹和稳定的包裹颗粒。