间隙连接结构的历史：从六边形阵列到原子分辨率。
A history of gap junction structure: hexagonal arrays to atomic resolution.
作者信息
Grosely Rosslyn, Sorgen Paul L
机构信息
Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA.
出版信息
Cell Commun Adhes. 2013 Feb;20(1-2):11-20. doi: 10.3109/15419061.2013.775256. Epub 2013 Mar 8.
Abstract
Gap junctions are specialized membrane structures that provide an intercellular pathway for the propagation and/or amplification of signaling cascades responsible for impulse propagation, cell growth, and development. Prior to the identification of the proteins that comprise gap junctions, elucidation of channel structure began with initial observations of a hexagonal nexus connecting apposed cellular membranes. Concomitant with technological advancements spanning over 50 years, atomic resolution structures are now available detailing channel architecture and the cytoplasmic domains that have helped to define mechanisms governing the regulation of gap junctions. Highlighted in this review are the seminal structural studies that have led to our current understanding of gap junction biology.
摘要
间隙连接是一种特殊的膜结构，它为负责冲动传播、细胞生长和发育的信号级联反应的传播和/或放大提供了一条细胞间途径。在确定构成间隙连接的蛋白质之前，通道结构的阐明始于对连接相邻细胞膜的六边形连接子的初步观察。伴随着跨越50多年的技术进步，现在已经有了原子分辨率结构，详细说明了通道结构以及有助于定义间隙连接调节机制的细胞质结构域。本综述重点介绍了那些引领我们目前对间隙连接生物学理解的开创性结构研究。
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1
¹H, ¹³C, and ¹⁵N backbone resonance assignments of the connexin43 carboxyl terminal domain attached to the 4th transmembrane domain in detergent micelles.在去污剂胶束中与第4个跨膜结构域相连的连接蛋白43羧基末端结构域的¹H、¹³C和¹⁵N主链共振归属
Biomol NMR Assign. 2013 Oct;7(2):299-303. doi: 10.1007/s12104-012-9432-8. Epub 2012 Oct 13.
2
Phosphorylation controls the interaction of the connexin43 C-terminal domain with tubulin and microtubules.磷酸化控制连接蛋白 43 C 端结构域与微管蛋白和微管的相互作用。
Biochemistry. 2012 May 29;51(21):4331-42. doi: 10.1021/bi201806j. Epub 2012 May 14.
3
Asymmetric configurations and N-terminal rearrangements in connexin26 gap junction channels.连接蛋白 26 缝隙连接通道中的不对称构象和 N 端重排。
J Mol Biol. 2011 Jan 21;405(3):724-35. doi: 10.1016/j.jmb.2010.10.032. Epub 2010 Nov 20.
4
Optimizing the solution conditions to solve the structure of the Connexin43 carboxyl terminus attached to the 4(th) transmembrane domain in detergent micelles.优化溶液条件以解析去污剂胶束中与第4个跨膜结构域相连的连接蛋白43羧基末端的结构。
Cell Commun Adhes. 2010 Apr;17(2):23-33. doi: 10.3109/15419061.2010.487956.
5
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J Biol Chem. 2009 Dec 4;284(49):34257-71. doi: 10.1074/jbc.M109.039594. Epub 2009 Oct 5.
6
Structural studies of the N-terminus of Connexin 32 using 1H NMR spectroscopy.使用核磁共振氢谱对连接蛋白32的N端进行结构研究。
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7
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