Beyoglu Eye Education and Research Hospital, Istanbul, Turkey.
Curr Eye Res. 2013 May;38(5):563-8. doi: 10.3109/02713683.2013.774025. Epub 2013 Mar 7.
To quantitatively assess the parameters of anterior chamber and angle dimensions by anterior segment optical coherence tomography (AS-OCT) in nanophthalmos.
In this prospective, cross-sectional and comparative study, 34 eyes of 34 healthy individuals (control group) and 37 eyes of 37 patients with nanophthalmos (study group) were enrolled. A single experienced ophthalmologist imaged and measured the right eye with the Visante AS-OCT. The anterior chamber angle (ACA), angle opening distance (AOD) at 500 and 750 µm from the scleral spur, and trabecular-iris space area (TISA) at 500 and 750 µm at the nasal and temporal angles were measured.
Mean nasal/temporal ACA was 44.90 ± 9.09/47.07 ± 8.69° in the control group and 32.15 ± 10.30/29.77 ± 10.57° in the study group (p < 0.001). Mean nasal/temporal AOD500 and AOD750 was 0.52 ± 0.18/0.53 ± 0.15 mm and 0.71 ± 0.26/0.71 ± 0.23 mm in the control group. The mean nasal/temporal AOD500 and AOD750 were 0.33 ± 0.12/0.31 ± 0.15 mm and 0.48 ± 0.16/0.47 ± 0.22 mm in the study group. Mean nasal/temporal TISA500 and TISA750 were 0.16 ± 0.06/0.17 ± 0.05 mm(2) and 0.31 ± 0.11/0.33 ± 0.09 mm(2) in the control group. Mean nasal/temporal TISA500 and TISA750 were 0.11 ± 0.04/0.09 ± 0.05 mm(2) and 0.20 ± 0.07/0.20 ± 0.10 mm(2) in the study group. All values were significantly lower in the study group compared with the control group.
Determination of angle parameters using AS-OCT is a rapid noncontact method that is useful in patients with nanophthalmos. The findings demonstrated that nanophthalmic eyes had lower ACA parameters including ACA, AOD500, AOD750, TISA500 and TISA750 at the nasal and temporal angles.
通过眼前节光学相干断层扫描（AS-OCT）定量评估先天性小眼球患者前房和房角参数。
本前瞻性、横断面和对照研究纳入了 34 只右眼（34 名健康个体，对照组）和 37 只右眼（37 名先天性小眼球患者，研究组）。由一名经验丰富的眼科医生使用 Visante AS-OCT 对右眼前节进行成像和测量。测量巩膜突 500μm 和 750μm 处的房角（ACA）、房角开口距离（AOD）和鼻侧和颞侧 500μm 和 750μm 处的小梁虹膜空间面积（TISA）。
对照组平均鼻侧/颞侧 ACA 为 44.90±9.09°/47.07±8.69°，研究组为 32.15±10.30°/29.77±10.57°（p<0.001）。对照组平均鼻侧/颞侧 AOD500 和 AOD750 分别为 0.52±0.18/0.53±0.15mm 和 0.71±0.26/0.71±0.23mm，研究组分别为 0.33±0.12/0.31±0.15mm 和 0.48±0.16/0.47±0.22mm。对照组平均鼻侧/颞侧 TISA500 和 TISA750 分别为 0.16±0.06/0.17±0.05mm² 和 0.31±0.11/0.33±0.09mm²，研究组分别为 0.11±0.04/0.09±0.05mm² 和 0.20±0.07/0.20±0.10mm²。与对照组相比，研究组所有值均显著降低。
使用 AS-OCT 确定房角参数是一种快速的非接触方法，在先天性小眼球患者中很有用。研究结果表明，小眼球眼的鼻侧和颞侧 ACA 及 AOD500、AOD750、TISA500 和 TISA750 等房角参数均较低。
