Cardiology Department and Cardiac Catheterization Laboratory, Athens General Hospital G. Gennimatas, Athens, Greece.
Curr Top Med Chem. 2013;13(2):216-30. doi: 10.2174/1568026611313020009.
MicroRNAs are small RNA molecules and constitute a relatively novel class of gene expression regulators, found in the great majority of eukaryotic cells. Their role in human physiology and pathology is actively being researched with new exciting discoveries continuously coming to the forefront. MicroRNAs play a crucial role in the biogenesis and function of the cardiovascular system and act as important regulators of various metabolic and signaling pathways in cardiovascular disease. In this review there will be a summary on current knowledge about the expression, regulation and function of microRNAs in the most common diseases of the cardiovascular system as well as a presentation of and discussion about their promising future role as new biomarkers and therapeutic targets.
MicroRNAs 是小 RNA 分子，构成了相对新颖的一类基因表达调控因子，存在于绝大多数真核细胞中。它们在人类生理学和病理学中的作用正在被积极研究，新的令人兴奋的发现不断涌现。MicroRNAs 在心血管系统的发生和功能中起着至关重要的作用，并作为心血管疾病中各种代谢和信号通路的重要调节剂。在这篇综述中，将总结 MicroRNAs 在心血管系统最常见疾病中的表达、调节和功能的最新知识，并介绍和讨论它们作为新的生物标志物和治疗靶点的有前途的未来作用。
