Orbital Unit, Department of Visual Science, University of Naples Federico II, Napoli, Italy.
Ophthalmic Plast Reconstr Surg. 2013 Mar-Apr;29(2):79-86. doi: 10.1097/IOP.0b013e31827a7622.
To evaluate the frequencies of orbital space-occupying lesions seen at single orbital unit in a period of 35 years.
In this retrospective case series, the authors reviewed the medical records of 2,480 consecutive patients referred to the authors' Orbital Unit for evaluation of an orbital mass between 1976 and 2011. The final diagnosis in each case was established by a combination of history, ocular findings, diagnostic imaging, and histopathologic analysis, when available. The number and percentage of benign and malignant tumors were determinated, also according to the age of the patients and the tumor location within the orbit. This study adhered to the principles of the Declaration of Helsinki.
Of the 2,480 lesions, 1,697 (68%) were benign and 783 (32%) were malignant. The most frequent benign tumors were dermoid cyst (14%) and cavernous hemangioma (9%). The most common malignant tumors were non-Hodgkin lymphoma (12%), basal cell carcinoma (3%), and orbital metastases (3%). In patients younger than 60 years, benign tumors are more frequent, whereas in patients older than 60 years, the frequency of malignant tumors increased. Regarding the distribution in the orbit, the most common tumors were dermoid cyst (206 cases) in the upper-outer quadrant, mucocele (155 cases) in the upper-inner quadrant, basal cell epithelioma (35 cases) in the lower-inner quadrant, cavernous hemangioma (68 cases) in the lower-outer quadrant, and meningioma (90 cases) in central space. Most of the tumors were located in the upper-outer quadrant. In the lower-inner quadrant, malignant tumors were more frequent than benign tumors.
The authors' findings highlight the distinctive nature of the orbital oncology experience at an ocular oncology department.
评估 35 年内单个眼眶单位内占位性病变的发生频率。
在这项回顾性病例系列研究中，作者对 1976 年至 2011 年间因眼眶肿块就诊于作者眼眶单位的 2480 例连续患者的病历进行了回顾性分析。在每种情况下，最终诊断均通过病史、眼部发现、诊断影像学和组织病理学分析确定，如有需要。根据患者年龄和肿瘤在眼眶内的位置，确定良性和恶性肿瘤的数量和百分比。本研究符合赫尔辛基宣言的原则。
在 2480 个病变中，1697 个（68%）为良性，783 个（32%）为恶性。最常见的良性肿瘤是皮样囊肿（14%）和海绵状血管瘤（9%）。最常见的恶性肿瘤是非霍奇金淋巴瘤（12%）、基底细胞癌（3%）和眼眶转移瘤（3%）。在 60 岁以下的患者中，良性肿瘤更为常见，而在 60 岁以上的患者中，恶性肿瘤的频率增加。关于眼眶内的分布，最常见的肿瘤是上外象限的皮样囊肿（206 例）、上内象限的黏液囊肿（155 例）、下内象限的基底细胞上皮瘤（35 例）、下外象限的海绵状血管瘤（68 例）和中央空间的脑膜瘤（90 例）。大多数肿瘤位于上外象限。在下内象限，恶性肿瘤比良性肿瘤更为常见。
作者的发现强调了眼科肿瘤学部门眼眶肿瘤学经验的独特性。
