Casato M, Bonomo L, Caccavo D, Giorgi A
Clinica Medica III, University of Rome, Italy.
Clin Exp Dermatol. 1990 Mar;15(2):121-3. doi: 10.1111/j.1365-2230.1990.tb02047.x.
Auto-immune mechanisms, mostly cell mediated, have been described as the basic abnormality in polymyositis and dermatomyositis. We report here the case of a patient affected with dermatopolymyositis, resistant to therapy, who was treated with corticosteroids and cyclosporin. She presented with an infiltrative, erythematous rash on the neck, eyelids and cheeks and weakness of the proximal limb and cervical muscles. The dramatic and persistent response to cyclosporin obtained in this case represents a clear demonstration of the action of this drug in cases of dermatomyositis.
自身免疫机制，主要是细胞介导的，已被描述为多发性肌炎和皮肌炎的基本异常。我们在此报告一例皮肌炎患者，对治疗耐药，接受了皮质类固醇和环孢素治疗。她表现为颈部、眼睑和脸颊出现浸润性红斑皮疹，近端肢体和颈部肌肉无力。该病例中环孢素获得的显著且持续的反应清楚地证明了这种药物在皮肌炎病例中的作用。
