Heckmatt J, Hasson N, Saunders C, Thompson N, Peters A M, Cambridge G, Rose M, Hyde S A, Dubowitz V
Department of Paediatrics, Hammersmith Hospital, London.
Lancet. 1989 May 13;1(8646):1063-6. doi: 10.1016/s0140-6736(89)92456-2.
Juvenile dermatomyositis in fourteen children who had not responded fully to steroids and other immunosuppressants and who had had chronic active disease for an average of 3 years was successfully treated with cyclosporin. Twelve patients had serious complications of the disease or of previous treatment. The response to cyclosporin included recovery of muscle strength and function and resolution of complications. It was possible to stop steroids or to reduce the steroid dose, which had previously been difficult, in all fourteen patients. In general, a low dose of cyclosporin (2.5-7.5 mg/kg daily) was sufficient and no serious side-effects were seen.
14名儿童患青少年皮肌炎，对类固醇和其他免疫抑制剂治疗反应不完全，且患有慢性活动性疾病平均3年，使用环孢素治疗取得成功。12名患者有该疾病或先前治疗的严重并发症。环孢素治疗反应包括肌肉力量和功能恢复以及并发症消退。在所有14名患者中，此前难以做到的停用类固醇或减少类固醇剂量成为可能。一般来说，低剂量环孢素（每日2.5 - 7.5毫克/千克）就足够了，且未观察到严重副作用。
