Briggs Tracy A
Arthritis Res Ther. 2013 Mar 8;15(2):110. doi: 10.1186/ar4172.
A growing body of literature has demonstrated that the multifunctional glycoprotein osteopontin (OPN), has a role in type I interferon (IFN) production and may be involved in systemic lupus erythematosus (SLE) pathogenesis. A recent report has provided further support for this, demonstrating an association between raised baseline circulating plasma osteopontin (cOPN) levels and IFN, and an elevation in cOPN prior to the onset of both increased cumulative disease and end-organ damage. These associations were most marked in paediatric SLE, implying that cOPN may be a useful biomarker of disease activity in childhood lupus.
越来越多的文献表明，多功能糖蛋白骨桥蛋白（OPN）在I型干扰素（IFN）产生中起作用，可能参与系统性红斑狼疮（SLE）的发病机制。最近的一份报告为此提供了进一步的支持，证明基线循环血浆骨桥蛋白（cOPN）水平升高与IFN之间存在关联，并且在累积疾病增加和终末器官损伤发作之前cOPN升高。这些关联在儿童SLE中最为明显，这意味着cOPN可能是儿童狼疮疾病活动的有用生物标志物。
