Lee Y H, Song G G
Division of Rheumatology, Department of Internal Medicine, Korea University Medical Center, Korea University College of Medicine, Seoul, Korea.
Lupus. 2017 Feb;26(2):132-138. doi: 10.1177/0961203316655214. Epub 2016 Jul 11.
Objective This study aimed to systemically review the evidence regarding the relationship between circulating blood osteopontin (OPN) level and systemic lupus erythematosus (SLE), correlation between serum OPN levels and SLE activity, and association between OPN polymorphisms and SLE susceptibility. Methods We conducted a meta-analysis on the serum/plasma OPN levels in SLE patients and healthy controls, correlation coefficients between the circulating OPN level and SLE Disease Activity Index (SLEDAI) in SLE patients, and the association between OPN polymorphisms and SLE risk. Results Nine studies with 1938 SLE patients and 3037 controls were included. Meta-analysis revealed that, compared with the control group, the OPN level was significantly higher in the SLE group (SMD = 0.965, 95% CI = 0.337-1.393, p = 0.001) and in the SLE group with renal disease (SMD = 2.219, 95% CI = 0.681-3.757, p = 0.005). Meta-analysis of correlation coefficients showed a trend of positive correlation between the circulating OPN level and SLEDAI (correlation coefficient = 0.590, 95% CI = -0.025 to 0.881, p = 0.059). While no association was found between SLE and the OPN 707 T/C and 1083 G/A polymorphisms, a significant association was identified between the OPN 1239 C allele and SLE (OR = 1.192, 95% CI = 1.008-1.410, p = 0.040), and between the OPN 9250 C allele and SLE in Asians (OR = 2.070, 95% CI = 1.570-2.730, p = 2.5 × 10). Conclusions Our meta-analysis revealed a significantly higher circulating OPN level in SLE patients, a trend of positive correlation between OPN levels and SLE activity, and a significant association between OPN 1239 C/A and 9250 C/T polymorphisms, and SLE development.
目的 本研究旨在系统评价循环血骨桥蛋白（OPN）水平与系统性红斑狼疮（SLE）之间关系的证据、血清OPN水平与SLE活动度的相关性以及OPN基因多态性与SLE易感性的关联。方法 我们对SLE患者和健康对照者的血清/血浆OPN水平、SLE患者循环OPN水平与SLE疾病活动指数（SLEDAI）之间的相关系数以及OPN基因多态性与SLE风险的关联进行了荟萃分析。结果 纳入了9项研究，共1938例SLE患者和3037例对照。荟萃分析显示，与对照组相比，SLE组的OPN水平显著更高（标准化均数差[SMD]=0.965，95%可信区间[CI]=0.337-1.393，p=0.001），在有肾脏疾病的SLE组中也显著更高（SMD=2.219，95%CI=0.681-3.757，p=0.005）。相关系数的荟萃分析显示循环OPN水平与SLEDAI之间有正相关趋势（相关系数=0.590，95%CI=-0.025至0.881，p=0.059）。虽然未发现SLE与OPN 707 T/C和1083 G/A基因多态性之间存在关联，但发现OPN 1239 C等位基因与SLE之间存在显著关联（比值比[OR]=1.192，95%CI=1.008-1.410，p=0.040），在亚洲人中OPN 9250 C等位基因与SLE之间也存在显著关联（OR=2.070，95%CI=1.570-2.730，p=2.5×10）。结论 我们的荟萃分析显示SLE患者循环OPN水平显著更高，OPN水平与SLE活动度之间有正相关趋势，以及OPN 1239 C/A和9250 C/T基因多态性与SLE发生之间存在显著关联。
