Nephrology Section, Hospital de Elche, Elche, Spain.
Ren Fail. 2013;35(4):547-50. doi: 10.3109/0886022X.2013.773913. Epub 2013 Mar 11.
Renal involvement is an unusual but significant Behcet´s disease (BD) complication and AA amyloidosis appears to be the most common etiology. IL-6 is a pro-inflammatory cytokine with an important role in AA amyloidosis development. Tocilizumab (TCZ) is a humanized anti-IL-6 receptor antibody that has emerged as an effective and specific treatment in AA amyloidosis secondary to chronic inflammatory disorders. We report on a patient diagnosed with BD who developed nephrotic syndrome caused by renal AA amyloidosis with an excellent response to TCZ therapy.
肾脏受累是一种罕见但重要的白塞病（BD）并发症，AA 淀粉样变性似乎是最常见的病因。IL-6 是一种促炎细胞因子，在 AA 淀粉样变性的发展中起重要作用。托珠单抗（TCZ）是一种人源化抗 IL-6 受体抗体，已成为慢性炎症性疾病继发 AA 淀粉样变性的有效和特异性治疗药物。我们报告了一例 BD 患者，该患者发生了由肾 AA 淀粉样变性引起的肾病综合征，对 TCZ 治疗有极好的反应。
