School of Medicine and Biomedical Science, University at Buffalo, Buffalo, New York 14214, USA.
Immunol Invest. 2013;42(3):247-61. doi: 10.3109/08820139.2012.750667.
Acute lung injury is defined as inadequate oxygenation of the blood due to primary and secondary injuries of the lungs that limit normal gas exchange across the alveolar capillary membrane. The etiology of this clinical syndrome is generally either infectious or non-infectious. Early detection of the underlying pathophysiology of the disease and timely initiation of antibiotic therapy is crucial for treatment of infectious causes of acute lung injury. Inflammatory biomarkers have recently gained popularity in critical care medicine to differentiate these two clinically similar entities. We have reviewed a variety of biomarkers related to acute lung injury and their relative value in early diagnosis and management of these patients.
急性肺损伤被定义为由于肺部的原发性和继发性损伤导致血液供氧不足，从而限制了肺泡毛细血管膜的正常气体交换。这种临床综合征的病因通常是感染性的或非感染性的。早期发现疾病的潜在病理生理学，并及时开始抗生素治疗，对于治疗急性肺损伤的感染性原因至关重要。炎症生物标志物最近在重症监护医学中得到了广泛关注，以区分这两种临床相似的实体。我们已经回顾了各种与急性肺损伤相关的生物标志物及其在这些患者的早期诊断和管理中的相对价值。
