[非肿瘤性肺部疾病中的淋巴管。综述]
[Lymphatics in non-tumoral pulmonary diseases. Review].
作者信息
Kambouchner M, Bernaudin J-F
机构信息
Service d'anatomie pathologique, hôpital Avicenne, 93009 Bobigny, France.
出版信息
Rev Pneumol Clin. 2013 Jun;69(3):170-4. doi: 10.1016/j.pneumo.2012.12.008. Epub 2013 Mar 6.
Whereas lymphatics in pulmonary non-tumoral diseases have been less studied than blood microcirculation, they clearly play a significant role. This review is a short update on lymphatics in various non-tumoral pulmonary diseases, from asthma to interstitial pneumonitis, excluding lymphangioleiomyomatosis. A lymphatic remodelling has been evidenced in asthma as well as in acute or chronic (UIP as NSIP) interstitial lung diseases. Such a remodelling can be explained as a side effect of local changes in fluidics but could also be an active player in the fibrosing process. Moreover the association of juxta-alveloar lymphatics and granulomas provides new insights in the emergence of these lesions in pulmonary sarcoidosis.
尽管与血液微循环相比，肺部非肿瘤性疾病中的淋巴管研究较少，但它们显然发挥着重要作用。本综述简要介绍了从哮喘到间质性肺炎等各种非肿瘤性肺部疾病中的淋巴管情况，不包括淋巴管平滑肌瘤病。在哮喘以及急性或慢性（如特发性肺纤维化或非特异性间质性肺炎）间质性肺疾病中已证实存在淋巴管重塑。这种重塑可以解释为流体力学局部变化的副作用，但也可能是纤维化过程中的一个积极参与者。此外，肺泡旁淋巴管与肉芽肿的关联为肺结节病中这些病变的出现提供了新的见解。
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