Stump Benjamin, Cui Ye, Kidambi Pranav, Lamattina Anthony M, El-Chemaly Souheil
Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Am J Respir Cell Mol Biol. 2017 Sep;57(3):272-279. doi: 10.1165/rcmb.2016-0290TR.
Advances in our ability to identify lymphatic endothelial cells and differentiate them from blood endothelial cells have led to important progress in the study of lymphatic biology. Over the past decade, preclinical and clinical studies have shown that there are changes to the lymphatic vasculature in nearly all lung diseases. Efforts to understand the contribution of lymphatics and their growth factors to disease initiation, progression, and resolution have led to seminal findings establishing critical roles for lymphatics in lung biology spanning from the first breath after birth to asthma, tuberculosis, and lung transplantation. However, in other diseases, it remains unclear if lymphatics are part of the overall lung remodeling process or real contributors to disease pathogenesis. The goal of this Translational Review is to highlight some of the advances in our understanding of the role(s) of lymphatics in lung disease and shed light on the critical needs and unanswered questions that might lead to novel translational applications.
我们识别淋巴管内皮细胞并将其与血管内皮细胞区分开来的能力取得了进展，这推动了淋巴生物学研究的重要进展。在过去十年中，临床前和临床研究表明，几乎所有肺部疾病的淋巴管系统都会发生变化。为了解淋巴管及其生长因子在疾病发生、发展和消退中的作用所做的努力，已经产生了一些开创性的发现，确立了淋巴管在从出生后的第一口呼吸到哮喘、肺结核和肺移植等肺部生物学中的关键作用。然而，在其他疾病中，淋巴管是否是肺部整体重塑过程的一部分或疾病发病机制的真正促成因素仍不清楚。这篇转化性综述的目的是强调我们在理解淋巴管在肺部疾病中的作用方面取得的一些进展，并阐明可能导致新的转化应用的关键需求和未解决的问题。
