Laboratory of Organic Chemistry, Faculty of Pharmacy and Food Sciences and Institute of Biomedicine (IBUB), University of Barcelona, 08028, Barcelona, Spain.
Department of Nutrition, Food Sciences and Gastronomy, Faculty of Pharmacy and Food Sciences, and Institute of Nutrition and Food Safety (INSA-UB), University of Barcelona, 08921, Santa Coloma, de Gramanet, Spain.
Chemistry. 2019 Dec 10;25(69):15929-15933. doi: 10.1002/chem.201904045. Epub 2019 Nov 12.
The synthesis of enantiopure ABCE and ABCD tetracyclic advanced intermediates en route to madangamine alkaloids and studies for the construction of the triunsaturated 15-membered D ring of madangamine B and the saturated 13-membered D ring of madangamine E are reported.
本文报道了（+）-ABCE 和（+）-ABCD 四环稠合型高级中间体的对映纯合成，这些中间体是构建马唐宁类生物碱的关键步骤，同时还研究了马唐宁 B 的三不饱和 15 元 D 环和马唐宁 E 的饱和 13 元 D 环的构建。
