Ishigami Y, Masuzawa M, Miyoshi E, Kato M, Tamura K, Kanda M, Awazu K, Taniguchi K, Kurita M, Hayashi N
First Department of Internal Medicine, Osaka University Medical School, Japan.
J Hepatol. 1993 Sep;19(2):232-40. doi: 10.1016/s0168-8278(05)80577-x.
The indocyanine green (ICG) Finger Monitor system is a non-invasive indication of ICG concentrations in the blood. In this study, significant correlation was found between the sensor signal voltage and plasma ICG concentrations ranging from 0.04 mg/dl to 1.0 mg/dl (r = 0.998, P < 0.001) in vivo. The ICG clearance curve showed an initial sharp rise 20-30 s after bolus injection, followed by a small rise. The concentration then deceased exponentially. In 196 patients with chronic liver disease, there was a close correlation between the KICG (plasma disappearance rate) and R15 (blood retention ratio at 15 min) (r = 0.886, P < 0.001, r = 0.912, P < 0.001) and corresponding values calculated by the conventional ICG method. In 263 cases with chronic liver disease, the plasma disappearance rates calculated using this monitor (mean +/- S.D.) were 0.156 +/- 0.064 (n = 20) in the control group, 0.129 +/- 0.060 (n = 92) in the chronic hepatitis group, 0.048 +/- 0.025 (n = 59) in the cirrhosis group and 0.059 +/- 0.03, (n = 92) in the group with hepatocellular carcinoma. A significant difference in the plasma disappearance rate and blood retention ratios 15 min after injection of ICG using this system was observed between control cases and the chronic hepatitis and cirrhosis groups (P < 0.0001). In 36 cases, the time from injection to the appearance of ICG in the fingertip significantly decreased in the cirrhosis group (P < 0.01). The ICG Finger Monitor system was shown to be useful clinically as well as for research due to its accuracy and non-invasive nature.
吲哚菁绿（ICG）手指监测系统是一种用于非侵入性指示血液中ICG浓度的系统。在本研究中，在体内发现传感器信号电压与血浆ICG浓度在0.04mg/dl至1.0mg/dl范围内存在显著相关性（r = 0.998，P < 0.001）。ICG清除曲线显示在推注后20 - 30秒有一个初始的急剧上升，随后有一个小幅度上升。然后浓度呈指数下降。在196例慢性肝病患者中，KICG（血浆消失率）与R15（15分钟时的血液潴留率）之间存在密切相关性（r = 0.886，P < 0.001，r = 0.912，P < 0.001），且与通过传统ICG方法计算的相应值相关。在263例慢性肝病病例中，使用该监测器计算的血浆消失率（平均值±标准差）在对照组中为0.156±0.064（n = 20），在慢性肝炎组中为0.129±0.060（n = 92），在肝硬化组中为0.048±0.025（n = 59），在肝细胞癌组中为0.059±0.03（n = 92）。使用该系统观察到，在注射ICG后15分钟时，对照组与慢性肝炎和肝硬化组之间的血浆消失率和血液潴留率存在显著差异（P < 0.0001）。在36例病例中，肝硬化组从注射到指尖出现ICG的时间显著缩短（P < 0.01）。由于其准确性和非侵入性，ICG手指监测系统在临床和研究中均显示出有用性。
