Aminuddin Amilia, Zakaria Zaiton, Fuad Ahmad F, Kamsiah Jaarin, Othman Faizah, Das Srijit, Kamisah Yusof, Qodriyah Haji S, Jubri Zakiah, Nordin Nor Anita M, Ngah Wan Z
Department of Physiology, Universiti Kebangsaan Malaysia Medical Center, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, Malaysia.
Saudi Med J. 2013 Mar;34(3):266-75.
To determine the association between carotid femoral pulse wave velocity (PWVCF); augmentation index (AI); and high-sensitivity C reactive protein (hs-CRP) with metabolic syndrome (MetS), and to determine the influence of ethnicity on PWVCF and AI, and the association between high hs-CRP and increased PWV, and AI in MetS.
A cross-sectional study was conducted at Universiti Kebangsaan Malaysia Medical Center, Kuala Lumpur, Malaysia from September 2009 to September 2011. Three hundred and eighty men (Chinese and Malays) were recruited from the study. The PWVCF and AI were measured by Vicorder (SMT Medical, Wuerzburg, Germany). The hs-CRP level was also determined. We defined MetS using the International Diabetes Federation (IDF) and harmonized criteria.
Malays had higher AI compared to the Malaysian Chinese. Patients with MetS had higher PWVCF (IDF criteria: 8.5 [8.3-8.7] versus 8.2 [8.0-8.4] m/s, p=0.03; harmonized criteria: 8.5 [8.4-8.7] versus 8.2 [8.0-8.4] m/s, p=0.007) and hs-CRP (IDF criteria: 0.9+/-2.0 versus 0.4+/-1.1 mg/L, p=0.0007; harmonized criteria: 0.8+/-1.9 versus 0.4+/-1.1 mg/L, p=0.002) compared to non-MetS. In subjects with MetS, those with high hs-CRP (>3 mg/L) had higher PWVCF.
Augmentation index values were significantly higher in Malays compared with Malaysian Chinese. Metabolic syndrome was associated with increased PWVCF and hs-CRP. Patients with MetS and high hs-CRP were associated with higher PWVCF. The measurement of hs-CRP reflects the degree of subclinical vascular damage in MetS.
确定颈动脉股动脉脉搏波速度（PWVCF）、增强指数（AI）和高敏C反应蛋白（hs-CRP）与代谢综合征（MetS）之间的关联，确定种族对PWVCF和AI的影响，以及高hs-CRP与MetS中脉搏波速度增加和AI之间的关联。
2009年9月至2011年9月在马来西亚吉隆坡马来西亚国民大学医学中心进行了一项横断面研究。从该研究中招募了380名男性（华裔和马来裔）。使用Vicorder（德国维尔茨堡的SMT Medical公司）测量PWVCF和AI。还测定了hs-CRP水平。我们使用国际糖尿病联盟（IDF）和统一标准定义MetS。
与马来西亚华裔相比，马来人的AI更高。患有MetS的患者的PWVCF（IDF标准：8.5[8.3 - 8.7]对8.2[8.0 - 8.4]m/s，p = 0.03；统一标准：8.5[8.4 - 8.7]对8.2[8.0 - 8.4]m/s，p = 0.007）和hs-CRP（IDF标准：0.9±2.0对0.4±1.1mg/L，p = 0.0007；统一标准：0.8±1.9对0.4±1.1mg/L，p = 0.002）高于非MetS患者。在患有MetS的受试者中，hs-CRP高（>3mg/L）的患者PWVCF更高。
与马来西亚华裔相比，马来人的增强指数值显著更高。代谢综合征与PWVCF和hs-CRP升高有关。患有MetS且hs-CRP高的患者与更高的PWVCF有关。hs-CRP的测量反映了MetS中亚临床血管损伤的程度。
