Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aza-Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan.
J Org Chem. 2013 Apr 5;78(7):3438-44. doi: 10.1021/jo400056k. Epub 2013 Mar 21.
A silver trifluoromethanesulfonate (AgOTf)-promoted direct and mild formylation of benzenes has been developed. The reaction utilizing dichloromethyl methyl ether (Cl2CHOMe) and AgOTf powerfully formylated various substituted benzenes under temperature conditions as low as -78 °C without losing the protecting groups on the phenolic hydroxyl group.
一种三氟甲磺酸银（AgOTf）促进的苯的直接温和甲酰化方法已被开发出来。该反应利用二氯甲基甲醚（Cl2CHOMe）和 AgOTf，在低至-78°C 的温度条件下，强力地将各种取代的苯甲酰化，而不会使酚羟基上的保护基团失去。
