Surgery, Stony Brook University Hospital, Long Island, New York, NY, USA.
Perit Dial Int. 2013 Mar-Apr;33(2):116-23. doi: 10.3747/pdi.2012.00001.
In 2008, we initiated the first Guyanese comprehensive kidney replacement program, comprising hemodialysis (HD), peritoneal dialysis (PD), vascular access procedures, and living-donor kidney transplantation. The government of Guyana, US-based philanthropists, US-based physicians, and Guyanese caregivers teamed up to form a public-private partnership. This pilot program was free of cost to the patients.
From July 2010 to the time of writing, we placed 17 patients with end-stage kidney disease on PD, which was used as a bridge to living-donor kidney transplantation. During the same period, we placed 12 primary arteriovenous fistulae.
The 17 patients who received a PD catheter had a mean age of 43.6 years and a mean follow-up of 5.3 months. In that group, 2 deaths occurred (from multi-organ failure) within 2 weeks of catheter placement, and 2 patients were switched to HD because of inadequate clearance. Technical issues were noted in 2 patients, and 3 patients developed peritonitis (treated with intravenous antibiotics). An exit-site abscess in 1 patient was drained under local anesthesia. The peritonitis rate was 0.36 episodes per patient-year. Of the 17 patients who received PD, 4 underwent living-donor kidney transplantation.
In Guyana, PD is a safe and cost-effective option; it may be equally suitable for similar developing countries. In Guyana, PD was used as a bridge to living-donor kidney transplantation. We have been able to sustain this program since 2008 by making incremental gains and nurturing the ongoing public-private partnership.
2008 年,我们启动了首个圭亚那综合肾脏替代治疗项目,包括血液透析(HD)、腹膜透析(PD)、血管通路手术和活体供肾移植。圭亚那政府、美国慈善家、美国医生和圭亚那护理人员携手合作,建立了公私合作伙伴关系。该试点项目对患者免费。
自 2010 年 7 月至撰写本文时,我们对 17 名终末期肾病患者进行了 PD 治疗,将其作为活体供肾移植的桥接治疗。在此期间,我们共建立了 12 条初级动静脉瘘。
接受 PD 导管治疗的 17 名患者的平均年龄为 43.6 岁,平均随访时间为 5.3 个月。在这组患者中,导管放置后 2 周内有 2 例死亡(死于多器官衰竭),2 例患者因清除率不足而转为 HD。2 例患者出现技术问题,3 例患者发生腹膜炎(经静脉内抗生素治疗)。1 例患者出现出口部位脓肿,在局部麻醉下引流。腹膜炎发生率为 0.36 例/患者年。在接受 PD 治疗的 17 名患者中,有 4 名接受了活体供肾移植。
在圭亚那,PD 是一种安全且具有成本效益的选择;它可能同样适用于类似的发展中国家。在圭亚那,PD 被用作活体供肾移植的桥接治疗。自 2008 年以来,我们通过逐步取得进展和培育持续的公私合作伙伴关系,成功维持了该项目。