Specialty Chemicals Division, ZEON CORPORATION, 1-6-2 Marunouchi, Chiyoda-ku, Tokyo 100-8246, Japan.
Molecules. 2013 Mar 11;18(3):3183-94. doi: 10.3390/molecules18033183.
Cyclopentyl methyl ether (CPME) has been used in chemical synthesis as an alternative to hazardous solvents. According to some earlier investigation by others, CPME has low acute or subchronic toxicity with moderate irritation and negative mutagenicity and negative skin sensitization (Local Lymph Node Assay). Calculated Permitted Daily Exposure (PDE) value of CPME obtained by our 28-day oral toxicity test is 1.5 mg/day, and CPME is thus assumed to be a class 2 equivalent solvent in the ICH (International Conference on Harmonization) Harmonized Tripartite Guideline Q3C (R5). Wide synthetic utility and a detailed toxicity study suggest CPME as a green and sustainable solvent of choice for modern chemical transformations.
环戊基甲醚（CPME）已被用于化学合成中，作为危险溶剂的替代品。根据其他人早些时候的一些研究，CPME 的急性或亚慢性毒性较低，具有中度刺激性，无致突变性和阴性皮肤致敏性（局部淋巴结试验）。我们通过 28 天口服毒性试验得出 CPME 的计算允许每日暴露量（PDE）值为 1.5mg/天，因此 CPME 被认为是 ICH（国际人用药品注册技术协调会）协调三方准则 Q3C（R5）中 2 类等效溶剂。广泛的合成实用性和详细的毒性研究表明，CPME 是现代化学转化中绿色和可持续溶剂的首选。
