Departamento de Química Orgánica, Universidad de Sevilla, c/ Profesor García González 2, 41012, Sevilla, Spain.
Department of Chemistry in Pharmaceutical Sciences, Section of Organic and Pharmaceutical Chemistry, Faculty of Pharmacy, Complutense University of Madrid, Plaza de Ramón y Cajal, s/n., E-28040, Madrid, Spain.
ChemSusChem. 2019 May 21;12(10):2083-2097. doi: 10.1002/cssc.201900079. Epub 2019 Apr 12.
The quest for sustainable solvents is currently a matter of intense research and development, as solvents significantly contribute heavily to the waste generated by chemical industries. Cyclopentyl methyl ether (CPME) is a promising eco-friendly solvent with valuable properties such as low peroxide formation rate, stability under basic and acidic conditions, and relatively high boiling point. This Review discusses the potential use of CPME for applications in biotechnology (e.g., biotransformations, as solvent or cosolvent), biorefineries, and bioeconomy (e.g., for furan synthesis or as an extractive agent in liquid-liquid separations), as well as for other purposes, such as chromatography or peptide synthesis. Although CPME is currently produced by petrochemical means with a remarkably high atom economy, its biogenic production can be envisaged from substrates such as cyclopentanol or cyclopentanone, which can be derived from furfural or from (bio-based) adipic acid, respectively. The combination of the promising properties of CPME as a (co)solvent with a future (economic) biogenic origin would be advantageous for setting strategies aligned with the sustainable chemistry principles.
目前，对可持续溶剂的探索是一个备受关注的研究和开发课题，因为溶剂会极大地加重化学工业所产生的废物量。环戊基甲醚 (CPME) 是一种很有前途的环保型溶剂，具有低过氧化物生成率、在酸碱条件下稳定以及相对较高沸点等宝贵特性。本综述讨论了 CPME 在生物技术（例如生物转化、作为溶剂或共溶剂）、生物精炼厂和生物经济（例如用于呋喃合成或作为液-液分离中的萃取剂）以及其他用途（例如色谱或肽合成）中的潜在应用。尽管 CPME 目前是通过石化方法以非常高的原子经济性生产的，但可以设想从环戊醇或环戊酮等底物中生物合成 CPME，这些底物可以分别从糠醛或（生物基）己二酸衍生而来。将 CPME 作为（共）溶剂的有前景的特性与未来（经济）生物起源相结合，将有利于制定符合可持续化学原则的策略。
