DeQuattro V, Miura Y, Lurvey A, Cosgrove M, Mendez R
Circ Res. 1975 Jan;36(1):118-26. doi: 10.1161/01.res.36.1.118.
Systemic biochemical indexes of sympathetic nerve functionplasma catecholamine concentrations and serum dopamine-beta-hydroxylase activitywere correlated with regional indexesnorepinephrine concentration activities of norepinephrine biosynthetic enzymes in the vas deferensānd with blood pressures and pulse rates of 57 men at the time of vasectomy. Mean plasma catecholamine content was increased 66% and 60% in men with elevated systolic and elevated systolic and diastolic blood pressures, respectively. The norepinephrine concentration, tyrosine hydroxylase activity, and dopa decarboxylase activity in the vas deferens were increased in 12%, 26%, and 17% of the men with elevated blood pressure, respectively. Tyrosine hydroxylase and dopa decarboxylase in the men with elevated systolic blood pressure were increased 41% and 68%, respectively, compared with values in the men with normal blood pressure (P less than 0.05 and P less than 0.02). Individual plasma catecholamine content was related directly to both systolic and mean blood pressure (P less than 0.01) and to activities of vas deferens tyrosine hydroxylases (P less than 0.05) and dopa decarboxylase (P less than 0.01). There was a weak, but not significant, correlation of plasma catecholamine concentration with serum dopamine-beta-hydroxylase activity. Raised plasma catecholamine concentration in men with elevated blood pressure prior to vasectomy was associated with increased neurotransmitter biosynthesis in their vas deferens, which may indicate increased sympathetic nerve tonicity and perhaps be a factor contributing to the blood pressure elevation.
交感神经功能的全身生化指标——血浆儿茶酚胺浓度和血清多巴胺-β-羟化酶活性，与局部指标——输精管中去甲肾上腺素浓度、去甲肾上腺素生物合成酶的活性，以及57名男性输精管结扎时的血压和脉搏率相关。收缩压升高和收缩压及舒张压均升高的男性，其平均血浆儿茶酚胺含量分别增加了66%和60%。血压升高的男性中，分别有12%、26%和17%的人输精管中的去甲肾上腺素浓度、酪氨酸羟化酶活性和多巴脱羧酶活性增加。与血压正常的男性相比，收缩压升高的男性其酪氨酸羟化酶和多巴脱羧酶分别增加了41%和68%（P<0.05和P<0.02）。个体血浆儿茶酚胺含量与收缩压和平均血压均直接相关（P<0.01），与输精管酪氨酸羟化酶活性（P<0.05）和多巴脱羧酶活性（P<0.01）也直接相关。血浆儿茶酚胺浓度与血清多巴胺-β-羟化酶活性之间存在微弱但不显著的相关性。输精管结扎术前血压升高的男性，其血浆儿茶酚胺浓度升高与输精管中神经递质生物合成增加有关，这可能表明交感神经张力增加，或许是导致血压升高的一个因素。
