演示一种基于蔗糖的对比剂，用于胃肠道磁共振成像。
Demonstration of a sucrose-derived contrast agent for magnetic resonance imaging of the GI tract.
机构信息
Department of Cancer Imaging and Metabolism, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
出版信息
Bioorg Med Chem Lett. 2013 Apr 1;23(7):2061-4. doi: 10.1016/j.bmcl.2013.02.008. Epub 2013 Feb 13.
Abstract
A scaffold bearing eight terminal alkyne groups was synthesized from sucrose, and copies of an azide-terminated Gd-DOTA complex were attached via copper(I)-catalyzed azide-alkyne cycloaddition. The resulting contrast agent (CA) was administered by gavage to C3H mice. Passage of the CA through the gastrointestinal (GI) tract was followed by T1-weighted magnetic resonance imaging (MRI) over a period of 47h, by which time the CA had exited the GI tract. No evidence for leakage of the CA from the GI tract was observed. Thus, a new, orally administered CA for MRI of the GI tract has been developed and successfully demonstrated.
摘要
一种带有 8 个末端炔基的支架是由蔗糖合成的，通过铜（I）催化的叠氮-炔环加成反应将末端叠氮化物的 Gd-DOTA 复合物连接到支架上。通过灌胃将得到的造影剂（CA）给予 C3H 小鼠。通过 T1 加权磁共振成像（MRI）在 47 小时的时间内监测 CA 通过胃肠道（GI）的过程，此时 CA 已经离开 GI 道。未观察到 CA 从 GI 道泄漏的迹象。因此，开发了一种新的、可口服的用于胃肠道 MRI 的 CA，并成功进行了验证。
相似文献
1
Demonstration of a sucrose-derived contrast agent for magnetic resonance imaging of the GI tract.
Bioorg Med Chem Lett. 2013 Apr 1;23(7):2061-4. doi: 10.1016/j.bmcl.2013.02.008. Epub 2013 Feb 13.
2
Sources of heterogeneous contrast enhancement in the gastrointestinal tract.
Magn Reson Imaging. 1994;12(7):1009-12. doi: 10.1016/0730-725x(94)91231-k.
3
A neutral polydisulfide containing Gd(III) DOTA monoamide as a redox-sensitive biodegradable macromolecular MRI contrast agent.
Contrast Media Mol Imaging. 2016 Jan-Feb;11(1):32-40. doi: 10.1002/cmmi.1655. Epub 2015 Jul 27.
4
Ultrasmall graphene oxide based T MRI contrast agent for in vitro and in vivo labeling of human mesenchymal stem cells.
Nanomedicine. 2018 Oct;14(7):2475-2483. doi: 10.1016/j.nano.2017.03.019. Epub 2017 May 26.
5
Synthesis and evaluation of a targeted nanoglobular dual-modal imaging agent for MR imaging and image-guided surgery of prostate cancer.
Pharm Res. 2014 Jun;31(6):1469-76. doi: 10.1007/s11095-013-1008-5. Epub 2013 Mar 8.
6
The interplay of T1- and T2-relaxation on T1-weighted MRI of hMSCs induced by Gd-DOTA-peptides.
Biomaterials. 2014 Apr;35(13):4168-74. doi: 10.1016/j.biomaterials.2014.01.073. Epub 2014 Feb 21.
7
Sequential fast 3D MRI following oral ingestion of Gd-DOTA: A new means to assess intestinal transit time.
J Magn Reson Imaging. 1999 Sep;10(3):474-6. doi: 10.1002/(sici)1522-2586(199909)10:3<474::aid-jmri32>3.0.co;2-q.
8
Gd-DOTA loaded into red blood cells, a new magnetic resonance imaging contrast agents for vascular system.
Adv Exp Med Biol. 1992;326:347-54. doi: 10.1007/978-1-4615-3030-5_42.
9
Design of a Gd-DOTA-phthalocyanine conjugate combining MRI contrast imaging and photosensitization properties as a potential molecular theranostic.
Photochem Photobiol. 2014 Nov-Dec;90(6):1376-86. doi: 10.1111/php.12332. Epub 2014 Oct 7.
10
Gadolinium-Labeled Aminoglycoside and Its Potential Application as a Bacteria-Targeting Magnetic Resonance Imaging Contrast Agent.
Anal Chem. 2018 Feb 6;90(3):1934-1940. doi: 10.1021/acs.analchem.7b04029. Epub 2018 Jan 17.
引用本文的文献
1
A novel gamma GLM approach to MRI relaxometry comparisons.
Magn Reson Med. 2020 Sep;84(3):1592-1604. doi: 10.1002/mrm.28192. Epub 2020 Feb 12.
2
Gd3+-1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic-2-hydroxypropyl-β-cyclodextrin/Pluronic Polyrotaxane as a Long Circulating High Relaxivity MRI Contrast Agent.
ACS Appl Mater Interfaces. 2015 Oct 14;7(40):22272-6. doi: 10.1021/acsami.5b05393. Epub 2015 Sep 29.
3
Magnesium pyrophosphates in enzyme mimics of nucleotide synthases and kinases and in their prebiotic chemistry.
Proc Natl Acad Sci U S A. 2015 Sep 29;112(39):12011-4. doi: 10.1073/pnas.1516239112. Epub 2015 Sep 14.
本文引用的文献
1
Design, Synthesis, and Testing of a Molecular Truck for Colonic Delivery of 5-Aminosalicylic Acid.
ACS Med Chem Lett. 2012 Sep 13;3(9):710-714. doi: 10.1021/ml300086c. Epub 2012 Aug 1.
2
A sucrose-derived scaffold for multimerization of bioactive peptides.
Bioorg Med Chem. 2011 Nov 1;19(21):6474-82. doi: 10.1016/j.bmc.2011.08.053. Epub 2011 Aug 27.
3
Radiation dose measurement in gastrointestinal studies.
Radiat Prot Dosimetry. 2011 Sep;147(1-2):118-21. doi: 10.1093/rpd/ncr277. Epub 2011 Jul 5.
4
Dendritic MRI contrast agents: an efficient prelabeling approach based on CuAAC.
Biomacromolecules. 2011 Aug 8;12(8):2902-7. doi: 10.1021/bm2004466. Epub 2011 Jul 15.
5
On the Synthesis of 1,4,7-Tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane.
Tetrahedron Lett. 2011 Apr 27;52(17):2058-2061. doi: 10.1016/j.tetlet.2010.10.074.
6
Molecular imaging and targeted therapies.
Biochem Pharmacol. 2010 Sep 1;80(5):731-8. doi: 10.1016/j.bcp.2010.04.011. Epub 2010 Apr 21.
7
High-resolution magnetic resonance colonography and dynamic contrast-enhanced magnetic resonance imaging in a murine model of colitis.
Magn Reson Med. 2010 Apr;63(4):922-9. doi: 10.1002/mrm.22229.
8
Copper-catalyzed azide-alkyne cycloaddition (CuAAC) and beyond: new reactivity of copper(I) acetylides.
Chem Soc Rev. 2010 Apr;39(4):1302-15. doi: 10.1039/b904091a. Epub 2010 Mar 4.
9
Gd(III)-nanodiamond conjugates for MRI contrast enhancement.
Nano Lett. 2010 Feb 10;10(2):484-9. doi: 10.1021/nl903264h.
10
Barrier-focused intervention to increase colonoscopy attendance among nonadherent high-risk populations.
World J Gastroenterol. 2009 Aug 21;15(31):3920-5. doi: 10.3748/wjg.15.3920.
Zotero 插件