Department of Medical Oncology, the Third Affiliated Hospital of Harbin Medical University, Harbin 150081, China.
Sci China Life Sci. 2013 Apr;56(4):335-40. doi: 10.1007/s11427-013-4435-y. Epub 2013 Mar 12.
We aimed to investigate risk factors of local and distant recurrence in small-sized, node negative breast cancer in women <35 years in a Chinese cohort. Between January 1994 and January 2007, 107 patients with pathologically confirmed small-sized ([Symbol: see text]1 cm), node negative breast cancer who did not receive neoadjuvant or adjuvant chemotherapy were included. The 5-year recurrence-free survival (RFS) was estimated according to different prognostic variables. With a median time of 60 months (range, 8-60 months) follow-up, local and distant recurrence were observed in 25 cases (23.4%). By univariate analysis, HER-2 positivity, triple negative (TN), and high Ki-67 index ([Symbol: see text]14%) were risk factors of a lower RFS (hazard ratio (HR) 6.680, 95% confidence interval (CI) 2.350-18.985, P<0.0001 for HER-2 positive; HR 4.769, 95%CI 1.559-14.591, P=0.006 for TN; HR 6.030, 95%CI 2.659-13.674, P<0.0001 for high Ki-67 index). Patients with grade 3 tumors had a lower RFS (HR 2.922, 95%CI 1.096-7.791, P=0.032) compared with those with grade 1 or grade 2 tumors. By multivariate analysis, HER-2 positivity (HR 10.204, 95%CI 3.391-30.704, P<0.0001), TN (HR 10.521, 95% CI 3.152-35.113, P<0.0001) and high Ki-67 index (HR 10.820, 95%CI 4.338-27.002, P<0.0001) remained risk factors of RFS. In this cohort, HER-2 positivity, triple negative and high Ki-67 index were independent risk factors of RFS in young patients with T1a,bN0 breast cancer. Subsequent pregnancy did not affect RFS.
我们旨在研究中国队列中 35 岁以下女性小肿瘤（[Symbol: see text]1 厘米）、淋巴结阴性乳腺癌的局部和远处复发的危险因素。1994 年 1 月至 2007 年 1 月期间，纳入了 107 例经病理证实的小肿瘤（[Symbol: see text]1 厘米）、淋巴结阴性乳腺癌患者，这些患者未接受新辅助或辅助化疗。根据不同的预后变量估计 5 年无复发生存率（RFS）。中位随访时间为 60 个月（范围 8-60 个月），25 例（23.4%）出现局部和远处复发。单因素分析显示，HER-2 阳性、三阴性（TN）和高 Ki-67 指数（[Symbol: see text]14%）是 RFS 较低的危险因素（危险比（HR）6.680，95%置信区间（CI）2.350-18.985，P<0.0001 为 HER-2 阳性；HR 4.769，95%CI 1.559-14.591，P=0.006 为 TN；HR 6.030，95%CI 2.659-13.674，P<0.0001 为高 Ki-67 指数）。与 1 级或 2 级肿瘤相比，3 级肿瘤患者的 RFS 较低（HR 2.922，95%CI 1.096-7.791，P=0.032）。多因素分析显示，HER-2 阳性（HR 10.204，95%CI 3.391-30.704，P<0.0001）、TN（HR 10.521，95%CI 3.152-35.113，P<0.0001）和高 Ki-67 指数（HR 10.820，95%CI 4.338-27.002，P<0.0001）仍然是 RFS 的危险因素。在该队列中，HER-2 阳性、三阴性和高 Ki-67 指数是年轻 T1a，bN0 乳腺癌患者 RFS 的独立危险因素。随后的妊娠并不影响 RFS。
