Movahedi Mohammad, Haghighat Shahpar, Khayamzadeh Maryam, Moradi Afshin, Ghanbari-Motlagh Ali, Mirzaei Hamidreza, Esmail-Akbari Mohammad
Cancer Research Centre, Shahid Beheshti University of Medical Science, Tehran, IR Iran ; Epidemiology Department, School of Public Health, ShahidBeheshti University of Medical Science, Tehran, IR Iran.
Iran Red Crescent Med J. 2012 Dec;14(12):798-804. doi: 10.5812/ircmj.3631. Epub 2012 Dec 6.
Breast cancer is the most common cancer among women worldwide. Based on the latest Iranian national cancer department report, the total number of women registered with breast cancer was 6976 cases during 2007. Five year survival is one of the indicators used for evaluation of the quality for care to different types of malignancies including breast cancer.
The aim of this study was to estimate survival rate of breast cancer in 6147 Iranian patients at a national level in different geographic regions.
6147 cases of breast cancer, which had telephone number and were diagnosed between 2001-2006, were called to obtain information about their life status. Survival estimates were calculated using the Kaplan-Meier method, and the survival probability was calculated for the overall cohort and in different categories of gender, age and pathologic type of tumor. Hazard ratios (HR) according to demographic and risk variables were calculated by Cox's proportional hazard model.
The overall 5-year survival rate was 71.0%. The mean survival time was different between men and women, which was statistically significant. The number of men involved with breast cancer was 172 (2.8%) of all cases. The 5-year survival rate for patients in age group 41-50 years was significantly higher than other age groups (P = 0.001). The likelihood of death was higher in patients with 61 years old or more years rather than those below forty years old (HR = 1.31; 95% CI: 1.12-1.55).
THE FINDINGS OF THIS STUDY MIGHT HELP IRANIAN HEALTH MANAGERS: 1) to be more conscious about geographical and regional determinants which will affect overall survival rate. 2) To carry preventive activities such as public education particularly in Iranian men. 3) To think about screening and early detection of breast cancer.
乳腺癌是全球女性中最常见的癌症。根据伊朗国家癌症部门的最新报告，2007年登记的乳腺癌女性患者总数为6976例。五年生存率是用于评估包括乳腺癌在内的不同类型恶性肿瘤护理质量的指标之一。
本研究的目的是在国家层面估计不同地理区域的6147名伊朗乳腺癌患者的生存率。
对6147例有电话号码且在2001年至2006年期间被诊断出的乳腺癌患者进行电话随访，以获取其生存状况信息。采用Kaplan-Meier方法计算生存估计值，并计算整个队列以及按性别、年龄和肿瘤病理类型分类的生存概率。根据人口统计学和风险变量，通过Cox比例风险模型计算风险比（HR）。
总体五年生存率为71.0%。男性和女性的平均生存时间不同，具有统计学意义。男性乳腺癌患者占所有病例的172例（2.8%）。41至50岁年龄组患者的五年生存率显著高于其他年龄组（P = 0.001）。61岁及以上患者的死亡可能性高于40岁以下患者（HR = 1.31；95%CI：1.12 - 1.55）。
本研究结果可能有助于伊朗卫生管理人员：1）更加关注影响总体生存率的地理和区域因素。2）开展预防活动，如公众教育，特别是针对伊朗男性。3）考虑乳腺癌的筛查和早期检测。
