Azarbakhsh Habibollah, Heiran Alireza, Askarinejad Amir, Hassanzadeh Jafar, Janfada Maryam, Mirahmadizadeh Alireza
Department of Epidemiology, Faculty of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Non-Communicable Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Iran J Public Health. 2024 Aug;53(8):1890-1897. doi: 10.18502/ijph.v53i8.16295.
There is an increase in the incidence of breast and gynecologic cancers in Iran during the last three decades. Literature is inadequate about the Years of Life Lost (YLL) attributed to these cancers in Iran.
Mortality data due to these cancers amongst females aged >20 yr from 2004 to 2019 was acquired from "Electronic Death Registry System", Fars Province, Iran. Using local health centers' databases and national census reports from 1996 to 2016, the age-standardized incidence rate (ASR) per 100,000 people were estimated. YLLs were calculated using the WHO's 2015 "YLL template".
During 2004-2019, 1886 and 829 deaths occurred due to breast and gynecologic cancers, respectively. The ASR due to breast and gynecologic cancers showed a significant increasing trend (<0.001 for each). The total YLL due to breast, cervical/uterine/vaginal/vulvar, and ovary cancers' deaths in the 16-year period were 33,077, 7,172 and 6,584 yr, respectively. The highest YLLs were observed in 50-59-year-old females, followed by 40-49- and 60-69-year-old females. The 16- year trend of YLL rate due to premature mortality in breast cancer, ovary cancer and cervix cancer was increasing: annual percent change (APC) was 7.6% (95% CI: 5.5-9.7, <0.001), 19.0% (95% CI: 12.2-26.1, <0.001) and 9.2% (95% CI: -9.2 to 31.3, >0.05, respectively.
Mortality rate and YLLs due to breast and gynecologic cancers have been increased in southern Iran during the last twenty years. Early detection programs and allocating treatments at early stages should be prioritized.
在过去三十年中，伊朗乳腺癌和妇科癌症的发病率有所上升。关于伊朗这些癌症导致的寿命损失年数（YLL）的文献资料不足。
从伊朗法尔斯省的“电子死亡登记系统”获取了2004年至2019年20岁以上女性因这些癌症导致的死亡数据。利用当地卫生中心的数据库和1996年至2016年的全国人口普查报告，估算了每10万人的年龄标准化发病率（ASR）。使用世界卫生组织2015年的“YLL模板”计算YLL。
2004年至2019年期间，分别有1886例和829例死亡是由乳腺癌和妇科癌症导致的。乳腺癌和妇科癌症的ASR呈显著上升趋势（每种趋势的P值均<0.001）。在这16年期间，乳腺癌、宫颈癌/子宫癌/阴道癌/外阴癌以及卵巢癌死亡导致的YLL总数分别为33077年、7172年和6584年。YLL最高的是50至59岁的女性，其次是40至49岁和60至69岁的女性。乳腺癌、卵巢癌和宫颈癌过早死亡导致的YLL率在16年期间呈上升趋势：年变化百分比（APC）分别为7.6%（95%CI：5.5 - 9.7，P<0.001）、19.0%（95%CI：12.2 - 26.1，P<0.001）和9.2%（95%CI：-9.2至31.3，P>0.05）。
在过去二十年中，伊朗南部乳腺癌和妇科癌症的死亡率及YLL有所增加。应优先开展早期检测项目并在早期阶段分配治疗资源。
