源于深层囊性胃炎的胃腺癌，表现为 KCNE2 表达缺失。
Gastric adenocarcinoma arising in gastritis cystica profunda presenting with selective loss of KCNE2 expression.
机构信息
Department of Molecular Pathology, Ehime University, Graduate School of Medicine, Ehime 791-0295, Japan.
出版信息
World J Gastroenterol. 2013 Feb 28;19(8):1314-7. doi: 10.3748/wjg.v19.i8.1314.
Abstract
Gastritis cystica profunda (GCP) is a rare condition caused by ectopic entrapment of gastric glands, probably secondary to the disruption of muscularis mucosae. GCP is often associated with gastric adenocarcinoma, and loss of the KCNE2 subunit from potassium channel complexes is considered a common primary target molecule leads to both GCP and malignancy. In this study, we, for the first time, analyzed the expression of KCNE2 in surgically excised tissue from human gastric cancer associated with GCP and confirmed that reduced KCNE2 expression correlates with disease formation.
摘要
深层囊性胃炎（GCP）是一种罕见的疾病，由胃腺异位嵌顿引起，可能继发于黏膜肌层的破坏。GCP 常与胃腺癌相关，钾通道复合物中 KCNE2 亚单位的缺失被认为是导致 GCP 和恶性肿瘤的共同主要靶分子。在这项研究中，我们首次分析了与 GCP 相关的人胃癌手术切除组织中 KCNE2 的表达，并证实 KCNE2 表达降低与疾病形成相关。
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