Mitomi H, Iwabuchi K, Amemiya A, Kaneda G, Adachi K, Asao T
Dept. of Pathology, Kitasato University, National Sagamihara Hospital, Kanagawa, Japan.
Scand J Gastroenterol. 1998 Nov;33(11):1226-9. doi: 10.1080/00365529850172610.
We report a rare case of gastritis cystica profunda (GCP) accompanied by carcinoma that developed in a 51-year-old Japanese man without antecedent gastric surgery. The polypoid tumor was located in the upper body of the resected stomach. Histologically, it was characterized by herniation of surface epithelium and cystic glands in the submucosa, muscularis propria, and subserosa. Marked chronic atrophic gastritis was found throughout the stomach, and dysplastic epithelia and a few adenocarcinoma cells were found in the deeper parts of the GCP. The Ki-67, p53, and p21WAF1/CIP1 labeling indices for the deeper part of the GCP were higher than those for the superficial parts or the surrounding mucosa, suggesting that both epithelial cell proliferation and p53-dependent p21WAF1/CIP1 expression in DNA-damaged cells, which might be associated with gastritis, are enhanced in line with penetration of glands. The underlying mechanisms might be linked in a chain of factors leading to malignancy.
我们报告了一例罕见的伴有癌的胃深部囊肿性胃炎（GCP），该病例发生在一名51岁未接受过胃部手术的日本男性身上。息肉样肿瘤位于切除胃的上半部分。组织学上，其特征为表面上皮和黏膜下层、固有肌层及浆膜下层的囊性腺体疝入。整个胃均发现有明显的慢性萎缩性胃炎，在GCP的深部发现了发育异常的上皮细胞和一些腺癌细胞。GCP深部的Ki-67、p53和p21WAF1/CIP1标记指数高于浅表部位或周围黏膜，这表明随着腺体的深入，DNA损伤细胞中的上皮细胞增殖和p53依赖的p21WAF1/CIP1表达均增强，这可能与胃炎有关。潜在机制可能与导致恶性肿瘤的一系列因素相关。
