Department of Dermatology, The University of Sydney, St Leonards, NSW 2065, Australia.
Biomed Res Int. 2013;2013:719570. doi: 10.1155/2013/719570. Epub 2013 Jan 2.
Activated protein C (APC) promotes angiogenesis and reepithelialisation and accelerates healing of diabetic ulcers. The aim of this study was to determine the relationship between the incidence of lower leg ulcers and plasma levels of APC's precursor, protein C (PC), in diabetic patients. Patients with diabetes who had a lower leg ulcer(s) for >6 months (n = 36) were compared with age-, type of diabetes-, and sex-matched subjects with diabetes but without an ulcer (n = 36, controls). Total PC was assessed using a routine PC colorimetric assay. There was a significantly (P < 0.001) lower level of plasma PC in patients with ulcers (103.3 ± 22.7, mean ± SD) compared with control (127.1 ± 34.0) subjects, when corrected for age and matched for gender and type of diabetes. Ulcer type (neuropathic, ischaemic, or mixed) was not a significant covariate for plasma PC levels (P = 0.35). There was no correlation between PC levels and gender, type of diabetes, HbA1c, or C-reactive protein in either group. In summary, decreased circulating PC levels are associated with, and may predispose to, lower leg ulceration in patients with diabetes.
活化蛋白 C（APC）可促进血管生成和上皮再形成，并加速糖尿病溃疡的愈合。本研究旨在确定糖尿病患者小腿溃疡的发生率与 APC 前体蛋白 C（PC）的血浆水平之间的关系。将患有>6 个月小腿溃疡的糖尿病患者（n=36）与年龄、糖尿病类型和性别匹配但无溃疡的糖尿病患者（n=36，对照组）进行比较。使用常规 PC 比色法评估总 PC。与对照组（127.1±34.0）相比，溃疡患者的血浆 PC 水平显著降低（P<0.001）（103.3±22.7，均值±标准差），同时校正了年龄、性别和糖尿病类型。溃疡类型（神经病变性、缺血性或混合性）不是影响 PC 水平的显著协变量（P=0.35）。在两组中，PC 水平与性别、糖尿病类型、HbA1c 或 C-反应蛋白均无相关性。总之，循环 PC 水平降低与糖尿病患者小腿溃疡的发生有关，并且可能使其易患溃疡。
