Department of Neurosurgery, Eberhard Karls University, 72076 Tübingen, Germany.
Biomed Res Int. 2013;2013:786475. doi: 10.1155/2013/786475. Epub 2013 Jan 15.
Cell transplantation, as a therapeutic intervention for spinal cord injury (SCI), has been extensively studied by researchers in recent years. A number of different kinds of stem cells, neural progenitors, and glial cells have been tested in basic research, and most have been excluded from clinical studies because of a variety of reasons, including safety and efficacy. The signaling pathways, protein interactions, cellular behavior, and the differentiated fates of experimental cells have been studied in vitro in detail. Furthermore, the survival, proliferation, differentiation, and effects on promoting functional recovery of transplanted cells have also been examined in different animal SCI models. However, despite significant progress, a "bench to bedside" gap still exists. In this paper, we comprehensively cover publications in the field from the last years. The most commonly utilized cell lineages were covered in this paper and specific areas covered include survival of grafted cells, axonal regeneration and remyelination, sensory and motor functional recovery, and electrophysiological improvements. Finally we also review the literature on the in vivo tracking techniques for transplanted cells.
细胞移植作为脊髓损伤 (SCI) 的一种治疗干预手段，近年来受到了研究人员的广泛研究。许多不同类型的干细胞、神经祖细胞和神经胶质细胞已经在基础研究中进行了测试，但由于各种原因，包括安全性和有效性，大多数都被排除在临床研究之外。实验细胞的信号通路、蛋白质相互作用、细胞行为以及分化命运已在体外进行了详细研究。此外，还在不同的动物 SCI 模型中研究了移植细胞的存活、增殖、分化以及对促进功能恢复的影响。然而，尽管取得了重大进展，但仍存在“从实验室到病床”的差距。本文全面涵盖了过去几年该领域的出版物。本文涵盖了最常用的细胞谱系，并特别涵盖了以下几个方面：移植细胞的存活、轴突再生和髓鞘形成、感觉和运动功能恢复以及电生理改善。最后，我们还回顾了用于移植细胞的体内示踪技术的文献。
