Dygai A M, Skurikhin E G, Ermakova N N, Pershina O V, Krupin V A, Reztsova A M, Ermolaeva L A, Khmelevskaya E S, Stepanova I E, Artamonov A V, Bekarev A A, Madonov P G, Kinsht D N, Goldberg V E, Semiglazova T A
Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk; Scientific Future Management Company, Novosibirsk, Russia.
Bull Exp Biol Med. 2013 Jan;154(3):329-33. doi: 10.1007/s10517-013-1943-5.
Using the model of lung fibrosis induced by intratracheal administration of bleomycin we studied anti-fibrotic activity of combined treatment with neuroleptic haloperidol and hyaluronidase immobilized on polyethylene oxide using electron-beam synthesis. It was shown that successive administration of immobilized hyaluronidase and the neuroleptic drug inhibits deposition of collagen fibers in the bleomycin-treated lungs. Combined treatment with the test compounds reduced swelling of the alveolar epithelium, exudation and infiltration of the alveolar interstitium and alveolar passages by inflammatory cells, and desquamation of alveolocytes into alveolar lumen, so that the alveolar-capillary membrane function was preserved.
我们采用气管内注射博来霉素诱导肺纤维化的模型，研究了抗精神病药物氟哌啶醇与通过电子束合成固定在聚环氧乙烷上的透明质酸酶联合治疗的抗纤维化活性。结果表明，连续给予固定化透明质酸酶和抗精神病药物可抑制博来霉素处理的肺中胶原纤维的沉积。测试化合物的联合治疗减少了肺泡上皮的肿胀、炎性细胞对肺泡间质和肺泡通道的渗出及浸润，以及肺泡细胞脱屑进入肺泡腔，从而保留了肺泡-毛细血管膜的功能。
